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Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Q2
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Imagine you were able to incorporate real and artificial amino acids with the following side chains into
proteins. Which of these would be most likely to be buried in the interior of the hemoglobin protein in its
folded form at ~pH 7.0? (Note that the non-ionized side chains are shown, and ionization will impact
solubility)
-H
O -CH2COOH
O -CH2OH
O -CH3"
Transcribed Image Text:QUESTION 2
Imagine you were able to incorporate real and artificial amino acids with the following side chains into
proteins. Which of these would be most likely to be buried in the interior of the hemoglobin protein in its
folded form at ~pH 7.0? (Note that the non-ionized side chains are shown, and ionization will impact
solubility)
-H
O -CH2COOH
O -CH2OH
O -CH3
Expert Solution
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Introduction
Proteins are composed of polypeptide chains. These polypeptide chains are made up of 20 different amino acids joined together via peptide chain. It is the variable side chain group of amino acids that make them hydrophilic or hydrophobic. Among the 20 amino acids, 8 are hydrophobic , 5 are uncharged hydrophilic, 3 are basic and 2 are acidic. The acidic and basic amino acids are also hydrophilic. The rest 2 amino acids are glycine and proline whose side chain groups are considered special.
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