Identify the objectives and methodology of the article below: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824784/ Riboswitches as Drug Targets for Antibiotics Vipul Panchal

Semi-synthetic and extended-spectrum penicillins have proven more effective than natural penicillins for two of the following reasons: 1-Interfere more effectively with the development of the peptidoglycan layer in cell-walls 2-Are less sensitive to penicillinases than natural penicillins 3-Do not contain the b-lactam ring thus making them less susceptible to b-lactamases 4-Are less susceptible to the development of resistance 5-Have a broader spectrum of activity

Indicate whether each statement is true or false, and justify your answer.Phase III clinical trials are a minor part of the drug development process in the US.

Please find the question

Apart from simple diffusion, suggest TWO ways how do drugs pass through the cell membrane and the properties of the drugs that is suitable for that way.

Discuss at least two novel antimicrobial strategies that are under investigation.

During clinical trial, which phase only focus on safety but not effectiveness of the tested drug? Phase 0 Phase 1 Phase 2 Phase 3 O Phase 4

Explain how to administer an IM injection utilising the Z-track method.

What is the objective of the journal below https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824784/ Riboswitches as Drug Targets for Antibiotics Vipul Panchal* and Ruth Brenk*

Why are the risks associated with antibiotics hard to understand?  Please describe in detail with reasoning in a supporting paragraph.