Apart from simple diffusion, suggest TWO ways how do drugs pass through the cell membrane and the properties of the drugs that is suitable for that way.
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Apart from simple diffusion, suggest TWO ways how do drugs pass through the cell membrane and the properties of the drugs that is suitable for that way.
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- Biotransformation is an important concept in pharmacology, which amongst others, enables the effective administration of prodrugs. Provide a detailed description of factors influencing the biotransformation of drugs.List all the possible modes of entry of the drug to the target cell membranes.Describe the influence of protein binding on drug bioavailability
- The mechanism of acquired drug resistance that would prohibit the drug molecule from entering a target cell would be considered: Use of alternate metabolic pathway Drug inactivation Activation of drug pumps Decreased permeability Change in drug binding sitePolymer nanoparticles, Microparticles and hydrogels have been developed for slow and sustained drug release for slow and sustained drug release application; mark all that apply below: 1)Drug release from hydrogels can be via (a) drug diffusion, (b) degradation of the polymeric matrix and (c) swelling 2) PLGA degrades to lactic acid and glycolic acid, which are not biocompatible 3) Drug release can be triggered through internal and external stimuli - I.e. by use of pH labile chemistries or external triggers 4) Burst release describes the initial faster release rates often observed in drug delivery system, which is then followed by sustained release 5) while burst release is observed with polymer nanoparticles, it is not observed from hydrogelshow does protein binding affect the drug action
- What are the different methods for developing modified release drug delivery system ? Discuss about the matrix and encapsulation drug release systems. Please explain at your own words.Whether an antimicrobial is broad spectrum or narrow spectrum depends on its mode of action. For the following 2 hypothetical drugs, predict whether they are broad spectrum or narrow spectrum. Explain your reasoning: 4. a. Drug A interferes with peptidoglycan synthesis - b. Drug B interferes with 70S ribosome function- c. Drug C interferes with synthesis of a vitamin –Draw the bacteria cell and indicate all the drug target in the bacteria cell and which drugs are able to attack each part.