IIIIIIII-111-2Aa1-111-3Aa1-2II-4III-1Example: Given the pedigree above, what is the probability that the granddaughter (III-1) will beheterozygous?In order to determine the probability that III-1 is heterozygous, we need to determine theprobability of the possible genotypes for her mother (II-2). Because the grandparents are bothheterozygous, we would expect the following genotypic ratios in their offspring: ¼ AA, ½ Aa,and 14 aa. However, we have to use all possible information, and the circle representing III-1 isnot shaded in, so she cannot be aa. Therefore, we eliminate the probability that II-2 is aa, and thefinal probability for II-2 is 1/3 AA and 2/3 Aa. We assume II-1 is AA because he is marryinginto the family and we assume everyone marrying into a family is homozygous wild-type, unlessproven otherwise.If II-2 is AA, and we assume II-1 is AA, then there is no chance that their daughter (III-1)is AaIf II-2 is Aa, and we assume II-1 is AA, then there is a 50% chance that their daughter(III-1) is AaWe add these two probabilities to get the final probability that III-1 is AaE. Through genetic analysis, we find that II-1 is actually heterozygous. Given this newinformation, what is the probability that his daughter (III-1) is heterozygous?F. If we change the genotype of the grandfather (I-1) to AA, what is the probabilitythat his granddaughter (III-1) is heterozygous? Continue to assume that II-1 isheterozygous.G. Let's go back to assuming that II-1 is AA. However, let's continue to say that I-1 isalso AA. What is the probability that III-1 is heterozygous?

Name: IIIIIIII-111-2Aa1-111-3Aa1-2II-4III-1Example: Given the pedigree abov
Uploaded: 2024-03-20T06:42:55.000Z
Channel: Bartleby
Description: IIIIIIII-111-2Aa1-111-3Aa1-2II-4III-1Example: Given the pedigree above, what is the probability that the granddaughter (III-1) will beheterozygous?In order to determine the probability that III-1 is heterozygous, we need to determine theprobability