Human cells divide every day for normal growth, replacement of cells, and tissue repair. The dividing cells proceed through the three phases of the cell cycle as shown in the figure. When a person experiences a cut, damaged skin cells secrete a protein called epidermal growth factor (EGF). Epidermal (skin) cells in the vicinity of the injury possess proteins in their cell membranes called epidermal growth factor receptors (EGFR) Cancer can result from disruptions in cell cycle control. Mutations that increase the production of EGFR have been associated with skin cancer of the head and neck. Describe how a mutation outside of the coding region of a gene that encodes EGFR could lead to the overproduction of EGFR protein in a skin cell.

Human cells divide every day for normal growth, replacement of cells, and tissue repair. The dividing cells proceed through the three phases of the cell cycle as shown in the figure. When a person experiences a cut, damaged skin cells secrete a protein called epidermal growth factor (EGF). Epidermal (skin) cells in the vicinity of the injury possess proteins in their cell membranes called epidermal growth factor receptors (EGFR) Cancer can result from disruptions in cell cycle control. Mutations that increase the production of EGFR have been associated with skin cancer of the head and neck. Describe how a mutation outside of the coding region of a gene that encodes EGFR could lead to the overproduction of EGFR protein in a skin cell.

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter22: Genes And Disease: Cancer

Section: Chapter Questions

Problem 3CT: Ultimately, cancer kills because it spreads and disturbs homeostasis. Consider, for example, a...

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Ultimately, cancer kills because it spreads and disturbs homeostasis. Consider, for example, a kidney cancer that metastasizes to the lungs and liver. What are some specific aspects of homeostasis that the spreading disease could affect?
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