Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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how geneticists perform association mapping, we need first to examine how variants at different sites across the genome tend to be organized with respect to each other in natural populations
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The association mapping is also called linkage disequilibrium and is a method of mapping QTLs. These are the quantitative trait loci and takes historic link advantage to link phenotype to genotype. A QTL is a locus and it correlates with the phenotype trait variation in a population.
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- In a series of mapping experiments, the recombination frequencies for four different linked genes of the Drosophila fly were determined, as shown in the figure. Based on this information, what is the most probable order of these genes on the chromosome? b 0 cn 90 rb 3.5 6.5 0 vg 19 9.0 16 0 b cn rb vg The numbers in the boxes are the recombination frequencies in between the genes (in percent). O b-rb-cn-vg O vg-cn-b-rb Orb-cn-vg-b b = black body cn = cinnabar eyes rb = reduced bristles vg = vestigial wings O vg-b-rb-cnarrow_forwardIn c. elegans, genetics model organism, movement problems (unc) and small body size (sma) are encoded by two mutant alleles that are recessive to those that produce wild-type traits (unc+ and sma+). A worm homozygous for movement problems and small body is crossed with a worm homozygous for the wild-type traits. The F1 have normal movement and normal body size. The F1 are then crossed with worms that have movement problems and small body size in a testcross. The progeny of this testcross is: Normal movement, normal body size 210 Movement problems, normal body size 9 Normal movement, small body size 11 Movement problems, small body size 193 a)From the test cross results, can you tell if the two genes are on the same chromosome or not? Explain your reasoning. b)What phenotypic proportions would be expected if the genes for round eyes and white body were located on different chromosomes? (please explain hot to get to these conclusions)arrow_forward**GENETICS** in genetic linkage and mapping why are we able to add up the individual distances to build the map?arrow_forward
- How can you use this piece of information to help you explain to your friends what is the significance of mutations in the emergence of new genetic properties (alleles) that may result (or not) in new phenotypic characteristics? (Recall that not all SNPs affect phenotype.)arrow_forwardCan you always ascertain an organism ‘s genotype for a particular locus if you know its phenotype? Conversely, if you are given an organism’s genotype for a locus, can you always reliably predict its phenotype? Explain.arrow_forwardin a randomly mating laboratory population of Drosophila, 4% of the flies have black bodies, and 96% have brown bodies. Flies with brown bodies always have at least one parent with a brown body. What is the frequency of heterozygotes in this population? 0.04 0.16 0.08 0.32 The period gene of Drosophila melanogaster encodes for a stretch of Thr-Gly repeated in tandem. In natural populations, the three most common alleles encode for 17, 20 and 23 Thr-Gly repeats. The amplification by PCR of the allele encoding for 20 Thr-Gly repeats produces a fragment of 320 bp. Using the same set of primers, what is the size expected when amplifying the 17 Thr-Gly allele? 317 303 314 302 in a certain species of plant loci A, B and C have an additive effect on the colour of the flower. Alleles A, B, and C are dominant and alleles a, b and c are recessive. Knowing that a plant with genotype AAbbCc has a…arrow_forward
- Which one of the following options most accurately describes how the ~3000 megabases (Mb; ~3,000,000,000 nucleotides) of the haploid human genome are distributed on chromosomes? The haploid human genome is distributed on autosomes 1-22 and X and Y (so, 24 chromosomes). The haploid human genome is distributed on the homologous pairs of autosomes 1-22 and X and Y (so, 46 chromosomes). The haploid human genome is distributed on a single chromosome (so, 1 chromosome). The haploid human genome is distributed on one pair of homologous chromosomes (so, 2 chromosomes).arrow_forwardA. How does the linkage of traits impact selection decisions in a breeding plan? B. How are molecular markers useful for making selection decisions in the face of linkage drag?arrow_forwardExplain Using temperature-sensitive alleles for time-of-function analysis?arrow_forward
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