How did the researchers kazutoshi takahashi and shinya yamanaka accomplish cellular reprogramming of a mouse fibroblast in their 2006 publication in cell?

Q: Researchers have artificially converted a mouse's lissencephalic cerebral cortex to a gyrencephalic…

A: A rare, genetically driven brain deformity known as lissencephaly, or "smooth brain," is…

Q: Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that…

A: Stem cells are defined by their ability to self-renew as well as differentiate into a variety of…

Q: Somatic death is:     A. Death of part of the organism     B. Death of the whole organism     C.…

A: Refer step 2 for answer

Q: If you were to design an experiment to get p53 back into cancer cells, how would you go about that…

A: p53 Is a nuclear transcription factor that promotes apoptosis. Because over 50% of human cancers…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Induced pluripotent stem cells (iPS) is a type of stem cell(pluripotent) in nature that is derived…

Q: a drug that inhibits metastasis, which of the following strategies is the WORST idea O to disrupt…

A: Metastasis is the part of the body that is the initial location of the start of cancerous cells and…

Q: Could you provide examples of stem cells that give rise to several types of differentiated cells…

A: The study of stem cells and their potential to distinguish into various types of cells could be an…

Q: There are several main model systems through which the first set of major breakthroughs in the…

A: The initial advances in our comprehension of cell cycle regulation are the topic of the question.…

Q: Metabolic syndrome is a clustering of various conditions including high blood pressure, high blood…

A: Metabolic syndrome is a group of disorders that occur in tandem and increase your risk of heart…

Q: Put the following types of stem cells in order from MOST useful in regenerative medicine to LEAST…

A: The correct option is b:  pluripotent--multipotent--totipotent--adult Explanation:  Totipotent cells…

Q: Below we are comparing two alleles: wildtype (functional) and mutant (not functional). Normally, p53…

A: Heterozygous  A condition where two different variety of a same allele present on different locus of…

Q: The protein AKT/PKB is a critical regulator of essential cellular processes, and dysregulation of…

A: Proteins have amino acids as their main constituents. Proteins and peptides are both lengthy…

Q: what is an inactivation gate?

A: Gating is a brief concept of transition between activation(opening) and inactivation(closing) of ion…

Q: In rats, the spinal nucleus of the bulbocavernosus undergoes greater a) apoptosis; females b)…

A: Introduction:- Apoptosis is a form of programmed cell death that occurs naturally in multicellular…

Q: Assume you have the factors in hand necessary to reprogram an adult cell, and the factors necessary…

A: The stem cells are an undifferentiated mass of cells used to treat damaged tissues. It is studied…

Q: Pick and define two terms that  use to describe the various proteins/enzymes or cellular processes…

A: "Transcription" and "Translation" are two words that are frequently used to refer to proteins,…

Q: Where are stem cells located in adult animals?

A: Stem cells are multipotent cells that have the ability to differentiate into different types of…

Q: Scientists have identified overexpression of Na+/K+ ATPases in several types of cancers plorectal…

A: It is given that we have to design a drug which is preventing the overexpression of the Na+/K+…

Q: What is an insulator? Describe two different ways that insulators may exert their effects.

A: Genes come in pairs and are responsible for the inheritance and expression of the associated…

Q: how would an inactive complex 1 lead to cell damage and cell death as seen in Parkinson’s patients ?

A: Inactive complex 1 can lead to formation of Reactive Oxidative species(ROS) and also reduces…

Q: Which of the following best describes this process of controlled cell in the web- bing of the…

A: During the development of human beings the webbing between fingers is broken down and spacing…

Q: Based on the data presented above, propose a molecular mechanism by which indibulin is active…

A: Indibulin is known as a small synthetic molecule. This compound is novel and is known to be orally…

Q: Are certain stem cells responsive to particular types of environmental stimuli and could we harness…

A: Stem cells have an interesting biology and offer enormous prospects for therapeutic applications.…

Q: Drug A323 inhibits the activity of the cyclin-dependent kinase (CDK) - G1 cyclin complex. Consider…

A: Answer 1:- Cyclin Dependent Kinases perforn an important role of controlling cell division and tune…

Q: he most likely explanation for why overexpression of Myc can have such different outcomes in normal…

A: In the question, following information is provided :Cancer cells : over expression. of Myc,…

Q: Which of the following is TRUE regarding the Steward's (1950s) carrot experiment and Gurdon et al.…

A: Two experiments, Steward et al. (1950s) and Gurdon et al. (1975), explored the role of nucleus and…

Q: Since all cells contain the same number of chromosomes and the overall same/similar genome how would…

A: In multicellular organisms, cells with the same genetic material can exhibit diverse functions and…

Q: In terms of ethical considerations, are there advantages/disadvantages to using ES and/or…

A: Answer well explained above

Q: What does "potency" mean in the context of stem cells? The power of cells to influence their…

A: The development of organisms in the embryonic stage goes through the differentiation of totipotent…

Q: Discuss the mechanisms by which transcription factors influence the reprogramming of somatic cells…

A: Somatic cells are similar to human beings in that they develop to fulfill a specific purpose in…

Q: Please explain the difference between Adult Stem Cell and Embryonic Stem Cells.

A: The differences between embryonic stem cells and adult stem cells.

Q: Cells of random sizes (some very small) are formed after cell division Normal sized cells are formed…

A: This ftsz protein that stands for filamentous temperature-sensitive protein Z plays a very important…

Q: You are growing up myoblasts C2C12 cells,to use in a myogenic study,You are using T-150 flasks with…

A: Nt = No 2^n n = t/g Where, Nt = final cell concentration No = initial cell concentration n = #…

Q: There are many compounds that have been advertised to reduce or delay aging. Resveratrol is a…

A: Resveratrol is a compound found in red wine and other plants that has been shown to have a variety…

Q: pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these…

A: The stem cells are the specific cells that can produce a complete plant or animal by the process of…

Q: How did the intrinsic pathway ofapoptosis evolve, and what is theadvantage of having…

A: When a cell becomes dead this is known as Apoptosis. In Apoptosis the material present in the cell…

Q: What is the purpose of systems cell? Please explain?

A: Systems cell is the study of the emergent properties of a cell and its components by using…

Q: Cystic fibrosis (CF) is a disorder caused by a random change in the gene that produces the cystic…

A: Cystic fibrosis is a genetic disorder that affects the lungs and digestive system. It is caused by a…

Q: Why is folding in the ER slow and inefficient and how are the misfolded ones degraded?

A: Endoplasmic reticulum-associated degradation (ERAD) is the QC check point of the ER which helps to…

Tissue regeneration & repair

Tissue regeneration involves the restoration of tissue components by regrowth of damaged tissues. In contrast, tissue repair involves patching of injured tissue rather than restoring it. It is the proliferative capacity of the cells that decides the amount of regeneration against the repair that would occur in the tissue. Both regeneration and repair depending on the duration of the injury and response to the inflammation.