Hospital pharmacies and drug manufactures have various gelatin capsules that they can put drugs into, which will only dissolve in acidic or basic media, once they pass the mouth. This will be done to control where the drug will be introduced into the human digestive tract. We do not want things dissolving in the mouth or oral cavity. Additionally, most drugs will have several different functional groups in their structure, or we can consider them polyfunctional group molecules. With that said, please answer the following questions in order: a) Where will a capsule designed to dissolve in a basic environment dissolve, after it is swallowedwith a glass of water? b) What will happen (if anything) to a part of the drug molecule that is an amine salt, once the capsule dissolves? (Consider what will happen to it in the same location In the digestive tract where the capsule dissolves.) c) What will happen (if anything) to a part of the drug molecule that is a carboxylic acid, once the capsule dissolves? (Consider what will happen to it in the same location in the digestive tract where the capsule dissolves.)

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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**Drug Delivery and Capsule Dissolution in Different Environments**

Hospital pharmacies and drug manufacturers have developed various gelatin capsules that can carry drugs which will only dissolve in specific acidic or basic media, *once they pass the mouth*. This control ensures that the drug is introduced precisely where needed in the human digestive tract. *We do not want things dissolving in the mouth or oral cavity.* Additionally, most drugs contain several different functional groups in their structure, often making them polyfunctional group molecules. With this context, please answer the following questions **in order**:

a) **Where will a capsule designed to dissolve in a basic environment dissolve, *after it is swallowed* with a glass of water?**

b) **What will happen (if anything) to a part of the drug molecule that is an amine salt, once the capsule dissolves? (Consider what will happen to it in the same location in the digestive tract where the capsule dissolves.)**

c) **What will happen (if anything) to a part of the drug molecule that is a carboxylic acid, once the capsule dissolves? (Consider what will happen to it in the same location in the digestive tract where the capsule dissolves.)**

d) **What will happen (if anything) to a part of the drug molecule that is an ether, once the capsule dissolves? (Consider what will happen to it in the same location in the digestive tract where the capsule dissolves.)**

e) **What will happen (if anything) to a part of the drug molecule that is an amine once the capsule dissolves? (Consider what will happen to it in the same location in the digestive tract where the capsule dissolves.)**
Transcribed Image Text:**Drug Delivery and Capsule Dissolution in Different Environments** Hospital pharmacies and drug manufacturers have developed various gelatin capsules that can carry drugs which will only dissolve in specific acidic or basic media, *once they pass the mouth*. This control ensures that the drug is introduced precisely where needed in the human digestive tract. *We do not want things dissolving in the mouth or oral cavity.* Additionally, most drugs contain several different functional groups in their structure, often making them polyfunctional group molecules. With this context, please answer the following questions **in order**: a) **Where will a capsule designed to dissolve in a basic environment dissolve, *after it is swallowed* with a glass of water?** b) **What will happen (if anything) to a part of the drug molecule that is an amine salt, once the capsule dissolves? (Consider what will happen to it in the same location in the digestive tract where the capsule dissolves.)** c) **What will happen (if anything) to a part of the drug molecule that is a carboxylic acid, once the capsule dissolves? (Consider what will happen to it in the same location in the digestive tract where the capsule dissolves.)** d) **What will happen (if anything) to a part of the drug molecule that is an ether, once the capsule dissolves? (Consider what will happen to it in the same location in the digestive tract where the capsule dissolves.)** e) **What will happen (if anything) to a part of the drug molecule that is an amine once the capsule dissolves? (Consider what will happen to it in the same location in the digestive tract where the capsule dissolves.)**
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