Hodgkin-Huxley type models represent the biophysical characteristic of cell membranes. The typical Hodgkin-Huxley model treats each component of an excitable cell as an electrical ele- ment, as shown in the figure. Extracellular medium gn(t,v) 60 w Intracellular medium (i) Explain the biological meanings of the capacitance (Cm), conductances (gn and gl), and batteries (E). (ii) State the equations for the current flowing through the lipid bilayer, and the current through a given ion channel. (iii) State the equation for the total current through the membrane of a cell with sodium and potassium channels. Explain the biophysical meaning of all parameters.

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Hodgkin-Huxley type models represent the biophysical characteristic of cell membranes. The typical Hodgkin-Huxley model treats each component of an excitable cell as an electrical ele- ment, as shown in the figure. Extracellular medium gn(t,v) 60 w Intracellular medium (i) Explain the biological meanings of the capacitance (Cm), conductances (gn and gl), and batteries (E). (ii) State the equations for the current flowing through the lipid bilayer, and the current through a given ion channel. (iii) State the equation for the total current through the membrane of a cell with sodium and potassium channels. Explain the biophysical meaning of all parameters. (iv) Ion pumps and exchangers are represented in the model by current sources (Ip). Explain how the sodium-potassium exchanger functions.

Hodgkin-Huxley type models represent the biophysical characteristic of cell membranes. The
typical Hodgkin-Huxley model treats each component of an excitable cell as an electrical ele-
ment, as shown in the figure.
Extracellular medium
Cm
gn(t,V)
En
Ej
Intracellular medium
(i) Explain the biological meanings of the capacitance (Cm), conductances (gn and g1), and
batteries (E).
(ii) State the equations for the current flowing through the lipid bilayer, and the current
through a given ion channel.
(iii) State the equation for the total current through the membrane of a cell with sodium and
potassium channels. Explain the biophysical meaning of all parameters.
(iv) Ion pumps and exchangers are represented in the model by current sources (Ip). Explain
how the sodium-potassium exchanger functions.
ww
Transcribed Image Text:Hodgkin-Huxley type models represent the biophysical characteristic of cell membranes. The typical Hodgkin-Huxley model treats each component of an excitable cell as an electrical ele- ment, as shown in the figure. Extracellular medium Cm gn(t,V) En Ej Intracellular medium (i) Explain the biological meanings of the capacitance (Cm), conductances (gn and g1), and batteries (E). (ii) State the equations for the current flowing through the lipid bilayer, and the current through a given ion channel. (iii) State the equation for the total current through the membrane of a cell with sodium and potassium channels. Explain the biophysical meaning of all parameters. (iv) Ion pumps and exchangers are represented in the model by current sources (Ip). Explain how the sodium-potassium exchanger functions. ww
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