he resting membrane potential of a neuron at 37°C is –60 mV (inside negative). If the freeenergy change associated with the transport of Na+ from o utside to in side is –10.0 kJ/mol, and [Na+]outside the cell is 260 mM, what is [Na+] inside the cell?gas constant R=8.315 J/mol.K; Faraday constant F=96.5 kJ/mol.vo
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The resting membrane potential of a neuron at 37°C is –60 mV (inside negative). If the freeenergy change associated with the transport of Na+ from o utside to in side is –10.0 kJ/mol, and [Na+]outside the cell is 260 mM, what is [Na+] inside the cell?gas constant R=8.315 J/mol.K; Faraday constant F=96.5 kJ/mol.volt
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- One of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?Consider a suspension of particles (isoelectric point is at pH 6) in water at pH 2 and a NaCl concentration of 0.001 M. Describe how the strength of repulsion varies with the following changes, assuming all other conditions remain constant. Give a description (more than just increase or decrease) in terms of the effect on the double layer thickness and the zeta potential. (a) Change from 0.001 M NaCl to 0.1 M NaCl, (b) Change from pH = 2 to pH = 5.Calculate the change in Gibbs free energy for transport of Ca2+ from outside to inside the cell. The extracellular Ca2+ concentration is 135 uM, and the intracellular Ca2+ concentration is 98 uM. The membrane potential is -22 mV and the temperature is 37°C. O. -5.1 kJ/mol O 1.2 kJ/mol -410 kJ/mol 3.4 kJ/mol
- A Br selective electrode is applied for measuring bromide ions in saline solution. Cl' ions were found to interfere, with a kPot = 0.0050. %3D After calibration, the ISE equation was determined to be y = -70 mV - 59.2mV*log(x). If we measure a potential of 93 mV, and the [CI]=0.100 M, what was the [Br'] in units of M? O 0.00821 O 0.100 O 0.0050 O 0.123 O Correct answer not found in other optionsWhat would be the free-energy change generated by the import of one mole of Na+ from a concentration of 10 mM to 150 mM with a membrane potential of −25 mV at 37°C? Give your answer without units and to one decimal place. F = 96.5 kJ/V•molThe protein calcineurin binds to the protein calmodulin with an association rate of 8.9 × 103 M−1 s −1 and an overall dissociation constant, Kd, of 10 nM. Calculate the dissociation rate, kd , including appropriate units.
- If experimental determinations of Kp at different temperatures for a given equilibrium in the temperature range 20-40 °C are fitted to the function shown below: In K, = a T2+c In() (a = 123.5 K?; = 23.6) %3D Answer the following questions: Calculate Kw at 5°C, assuming that AH° is temperature independent.Calculate the effective quantity (g) of sodium chloride related to tonicity in 100 mL of an intravenous fluid labeled "5% dextrose in 0.45% sodium chloride," and indicate whether the solution is isotonic, hypotonic, or hypertonic.For a typical vertebrate cell with a membrane potential of −0.070 V (inside negative), what is the free-energy change for transporting 1 mol of Na+ from the cell into the blood at 37 °C? Assume the concentration of Na+ insidethe cell is 12 mM and in blood plasma it is 145 mM.
- Given that the relative molecular mass of potassium chloride (KCl) is 74.5513 g mol-1, calculate the concentration of potassium chloride solution which will be iso-osmotic with tears (305 mOsM). State your answer in both molar concentration (mol/L) and in percentage (g/100 mL). Please answer very soon will give rating surelyHeart and muscle cells, where myoglobin resides, maintains an intracellular pO2 of about 2.5 torr. Calculate the fractional saturation (for human myoglobin) if a small change (1 torr) in oxygen partial pressure occurs in either direction (ie what happens at 1.5 torr, what happens at 3.5 torr?) and explain how a small change in oxygen pressure dramatically changes the myoglobin oxygen binding.Example The standard half electrode potential for Fe²+ vs SHE is 0.77 V. What is the value of Ee at T = 298K when: [Fe³+] = 0.2 mol l-1 [Fe2+] = 0.05 mol 1-1