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Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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
Transcribed Image Text:The figure shows that the average distance between base pairs measured parallel to the axis of a DNA molecule is 3.4 Å. The average molar mass of a pair of nucleotides is 650 g•mol-1. Estimate the length in cm of a DNA molecule of
molar mass 5.1x109
4.0 .26
g•mol-1.
cm
Roughly how many base pairs are contained in this molecule?
[4.0 784615
x base pairs
CG
G C
OH
TA
Thymine
Adenine
H.
H.
OH
CH2
N-H.......O
CH3
H
H
N……·H–N
HLH
TA
OH
0-P
H2C
CG
G C
H.
CH2
Guanine
H
OH
Cytosine
...
H-N
TA
AT
H'
N.....H-N
HLH
N-H.......O
H2C
OH
H
-o.
-P3D0
TA
0-
OH
H.
-CH2
(b) The most common structure of DNA, which is a right-handed double helix. The two strands are held together by hydrogen bonds
(a) Base-pair formation between adenine (A) and thymine (T) and between cytosine (C) and
guanine (G).
and other intermolecular forces.
Expert Solution
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- Write the base sequence and label the 3' and 5' ends of the complementary strand for a segment of DNA with the following base sequences: 5'CGGAC3'arrow_forwardA and B (adnine, cytosine, guanine, thymine) C and D (G1, G2, G3, G4)arrow_forwardThe figure shows that the average distance between base pairs measured parallel to the axis of a DNA molecule is 3.4 Å. The average molar mass of a pair of nucleotides is 650 g•mol-1. Estimate the length in cm of a DNA molecule of molar mass 5.1x109 g•mol-1. 4.0 cm Roughly how many base pairs are contained in this molecule? 4.0 7.1e6 X base pairs AT CG OH O-P=D0 G C TA Adenine Thymine OH CH2 N-H.......O CH3 H -N N..... G C H A Он C G G C TA AT OH CH2 Cytosine Guanine H. O.......H-N H H' H N…**H-N HLH O N-H..... H2C OH TA OH CH2 (b) The most common structure of DNA, which is a right-handed double helix. The two strands are held together by hydrogen bonds and other intermolecular forces. (a) Base-pair formation between adenine (A) and thymine (T) and between cytosine (C) and guanine (G).arrow_forward
- Consider normal B-form DNA. It forms a regular antiparallel double-helical structure with Watson-Crick base-pairing mediated through hydrogen bonding. The base pairs all stack upon one another, with 3.4 Å spacing between them. DNA strands having a complementary sequence will spontaneously form a double-helix in an aqueous solution. In terms of energy, what primarily drives helix formation? O Positive Entropy from base stacking van der Waals interactions O Hoogsteen interactions Positive Enthalpy from Hydrogen Bonding between GC and AT pairs Negative Enthalpy from Hydrogen Bonding between GC and AT pairs O Negative Entropy from base stackingarrow_forwardplease solve this with step-by-step calculations and explanations.arrow_forwardplease dont give hand writting solution pleasearrow_forward
- draw the structure of the polynucleotide GTarrow_forwardThe following is diagram of a generalized tetranucleotide. Carbons exist at corners on the shapes and phosphate groups are filled circles. A. Is this a DNA or an RNA Molecule? B. Where is the 3’ end of this tetranucleotide? C. Given that the DNA strand which served as a template for the synthesis of this tetranucleotide was composed of the bases 5’-ACAG-3’, where are the expected bases?arrow_forwardThe average length of double helix in human chromosome is 3.8cm. 1. Approximately how many base pairs would be present in such a chromosome?____________(no spaces and comma) 2. If the strand of nucleotide is 200,000 bp, give the length in micrometers.__________(no spaces)arrow_forward
- It is known that double stranded DNA is denatured at low pH. pKa values should allow the determination of whether this is due to perturbation of the hydrogen bonding in A-T and/or G-C base pairs. The table gives values for the pKas of different protonated groups in the nucleobases.Nucleobase Position & pKa A N1, 3.5 G N7, 1.6; N1, 9.2 C N3, 4.2 T N3, 9.7a) Draw the A-T and G-C base pairs. - Label the bases with the one-letter code. – - Number the atoms in the rings and label the atom that attaches to the sugar. - Mark the groups that interact in normal…arrow_forwardAs2arrow_forwardFirst please note this is DNA-B and NOT DNA-A, also the marked answer was wrong so please choose another onearrow_forward
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