FIG. 18.13 Relationship between number of genes and their effect on complex traits. Many Most of the genes affecting the trait have relatively small effects. For a typical complex trait, only a few genes have a relatively large effect. Few Small Large Magnitude of gene effect Number of genes affecting the trait
Q: Multifactorial inheritance Select all that apply. Traits that are determined by many genes and…
A: Multifactorial inheritance is a type of inheritance in which many factors are involved in causing a…
Q: Resistance to the poison warfarin is a genetically determined trait in rats. Homozygotes carrying…
A: The relative fitness is the reproductive or survival rate of a particular genotype with respect to…
Q: What characteristics do you expect to see in a trait that exhibits anticipation?
A: The trait is a characteristic feature of an organism which is present in an inherent form in a…
Q: Alleles - Any of the alternative versions of a gene that produce distinguishable phenotypic effects.…
A: Alleles are two separate forms of a gene. In each genetic locus, two alleles are present which are…
Q: What type of phenotypic effects might you expect from a large chromosome deficiency (deletion) that…
A: Deletion is a type of Chromosomal aberration in which there is loss of segment of a chromosome.In…
Q: In a population of 3000 fruit flies, 270 of them contain white eyes. White eye color is a recessive…
A: Introduction : Hardy – Weinberg Principle mathematically explains the occurrence and consistency of…
Q: What is the difference between and Genotypic Trait and a Phenotypic Trait. What do each of them…
A: Genetic material is nothing but the sequence of nucleic acids which is called as DNA. It contains…
Q: Height of the people is controlled by several pairs of genes, which interact by type of polymeria…
A: Height and other similar features are controlled not just by one gene, but rather, by multiple…
Q: How many mice would you expect to be homozygous dominant and heterozygous for
A: Dominant and recessive alleles alleles that can be expressed only when present in homozygous…
Q: Which of the following is most accurate? O phenotypes code for genotypes recessive alleles tend to…
A:
Q: The allele for tall is dominant to the allele for short in pea plants. Which of the following would…
A: The allele for tall is dominant over short as mentioned in the question. Let us consider, T for…
Q: A genetics researcher determines that the broad-sense heritability of height among Southwestern…
A: The term heritability refers to the extent of phenotypic disparity among the related species in a…
Q: Single gene Mendelian inheritance patterns: if you are told the phenotype of the parents and whether…
A: Since you have posted a question with multiple sub-parts, we will solve first three sub-parts for…
Q: Name several factors that influence variation incomplex traits.
A: A trait is defined as a specific characteristic of an organism. It is studied under the genetics of…
Q: What is meant by sayingthat in relation to a given traitconditioned by a gene withtwo different…
A: Gregor mendel is called as father of genetics. He proposed 3 laws such the law of segregation, law…
Q: Matching DNA samples in forensics uses a specific set of small “genes” called________ . The alleles…
A: Forensic science is the application of science to those criminal and civil laws that are enforced by…
Q: A responsible for anterior morphology in an organism is inherited as maternal effect gene. It has…
A: A maternal effect occurs when an organism's phenotype is influenced not only by its own environment…
Q: n individual that has two of the same alleles of a particular gene is said to be (blank)
A: An allele is a variant form of a gene. An individual inherits two alleles for each gene, one from…
Q: In some genes, like blood type, two alleles are expressed at the same time. What do we call this?…
A: Gene usually function or express themselves singly or individually. But many cases were seen by…
Q: Which of the following is not an example of a wild-type allele?a. Yellow-flowered elderflower…
A: An allele refers to a variant form of a mentioned gene. In certain occasions, distinct alleles can…
Q: Considering a common autosomal recessive trait: (Read each statement carefully. Select all of the…
A: Autosomal recessive: In this type the gene or condition is recessive type which means expressed in…
Q: In some kinds of cattle, there are two alleles for coat color, R for red and r for white. When an…
A: A scenario in which two separate alleles for a hereditary characteristic are both exhibited is known…
Q: If an individual is heterozygous for a particular trait Multiple Choice each parent contributed the…
A: There are two terms associated with gene. One of the terms is homozygous which indicates the…
Q: You are a scientist studying a population of beetles. Beetle color is controlled by two alleles at a…
A:
Q: One important example of multiple alleles is the human ABO blood type. Explain what “multiple…
A: The alleles at the alternative forms of a gene that are located on the same locus of a homologous…
Q: A heterozygous plant with genotype Aa self-pollinates, and then its offspring also self-pollinate.…
A: An heterozygous plant with genotype Aa self pollinates. From this we are able to predict the two…
Q: What are alleles? A) alternative forms of a genes for a single trait, such as blue eyes or brown…
A: The study of genetic variations, heredity, and genes is called genetics. The genetic or hereditary…
Q: Connection to Quantitative traits: SNPs are inherited in a Mendelian fashion and are often polygenic…
A: A quantitative trait is a phenotype that can be measured and is influenced by the interactions of…
Q: The dominant allele for tallness in plants is T, while the recessive allele for shortness is t. If a…
A: -The dominant alleles for tallness in plants is T, while the recessive allele for shortness is t.…
Q: You are crossing mice in your lab. You notice that there is heritable variability in the tail length…
A: Crossing mice in lab gives variability in the length of their tail due to the transfer of hereditary…
Q: Of the following groups, which would collectively share the most alleles? one niece, two first…
A: Allele sharing: The most number of alleles are shared by most related individuals. an allele is a…
Q: Mendel’s model organism for studying inheritance was the garden pea. What are the advantages of…
A: Gregor Mendel, known as the father of genetics, performed experiments with Garden pea and he gave…
Q: A heterozygous plant with genotype Aa self-pollinates, and then its offspring also self-pollinate.…
A: Introduction A gene is consisting of a pair of alleles/ factors and these alleles can be dominant…
Q: A green bird that has a white off spring A yellow bird that has a green parent A blue bird that has…
A: Allele Allele are the different form of a single gene located on same position on sister…
Q: Having freckles is a dominant trait in humans. A girl has freckles, but her brother does not. What…
A: Correct option is D) FF and ff
Q: With chickens, the trait for rose comb (R) is dominant over the trait for a single comb (r). A…
A: Mendel described some special types of crosses that can be used to check the inheritance of a…
Q: In a species of plant, some individuals have smooth leaves and some have hairy leaves. The character…
A: Given: A species of plant, some have smooth leaf and some have hairy leaf. To find: Simplest way to…
Q: A set of true (pure) breeding horses with white and black coats are bred together to make an F1…
A: * Given that set of pure breeding with white na black coats are bred together to make F1 generation.…
Q: The gene for lengths of stem in a garden pea plant results in either tall or short stems, with tall…
A: Tall plant (TT) = dominant trait. Short plant (tt) =recessive trait
Q: Suppose that height in a plant is controlled by 4 gene pairs. Each "dominant" allele (uppercase…
A: Height of the plant is controlled by 4 genes pairs, which are A,B,Cand D. The each dominant allele…
Q: A collection of all the alleles of all the genes of a crop plant are called?
A: All the alleles of all the genes of a crop plant is collected in plant breeding to evaluate the…
Q: Which of the following statements describes the multifactorial inheritance in genetics? O Phenotype…
A:
Q: Four pairs of monozygotic twins, who were separated tested for their ability to solve geometry…
A: According to the question, four pairs of monozygotic twins, who were separated immediately after…
Q: An F2 ratio of 12:3:1 is most characteristic of a genetic interaction involving? 1) two gene loci…
A: When two or more non-allelic gene influence the outcome of a single trait, this is known as gene…
Q: Two pigs of unknown genotype produce a litter of piglets, seven black and five white. If you know…
A: In genetics, the genes are the hereditary units. It consists of two alternative forms called the…
Q: Multiple alleles is described when a trait is controlled by more than two alleles, and that even if…
A: According to the question, here we will discuss that multiple alleles and lethal alleles are common…
Q: Whar is the probable pattern of inheritance and why
A: The pattern of inheritance is the manner in which a genetic trait or disorder is passed from one…
Q: In Mendel's experiments with peas, one single locus was responsible for determining whether a plant…
A: an allele is one of two or more version of same genes, at a same place on a chromosome. an allele…
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
When genes for complex traits have effects that are distributed as shown in Fig. 18.13,which are easier to identify: those that are numerous with small effects, or those that are few with large effects?
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- The Online Mendelian Inheritancein Man (OMIM) databaseis a catalog of human genesand human disorders that are inheritedin a Mendelian manner. Genetic disordersthat arise from major chromosomalaberrations, such as monosomyor trisomy(the loss of a chromosome orthe presence of a superfluous chromosome,respectively), are not included.The OMIM database, updated daily, is aversion of the book Mendelian Inheritancein Man, conceived and edited by Dr. VictorMcKusick of Johns Hopkins University,until he passed in 2008.The OMIM entries provide links to awealth of information, including DNAand protein sequences, chromosomalmaps, disease descriptions, and relevantscientific publications. In this exercise,you will explore OMIM to answer questionsabout the recessive human diseasesickle-cell anemia and other Mendelianinherited disorders.Exercise I – Sickle-Cell AnemiaIn this chapter, you were introduced torecessive and dominant human traits.You will now discover more about sicklecellanemia as an…Two alleles at one locus produce three distinctphenotypes. Two alleles of two genes lead tofive distinct phenotypes. Two alleles of six geneslead to 13 distinct phenotypes. (These statementsassume that the alleles at any one locus arecodominant or incompletely dominant andthat each gene makes an equal contributionto the phenotype.)a. Derive a formula to express this relationship. (Letn equal the number of genes.)b. Each of the most extreme phenotypes for a traitdetermined by two alleles at one locus are foundin a proportion of 1/4 in the F2 generation. If twoalleles of two genes determine the trait, each extreme phenotype will be present in the F2 as 1/16of the population.In common wheat (Triticum aestivum),kernel color varies from red to white andthe genes controlling the color act additively,that is, alleles for each gene are incompletelydominant and each gene contributes equallyto the color. A true-breeding red variety iscrossed to a true-breeding white variety, and1/256 of the F2…A DNA variant has been found linked to a rare autosomal dominant disease in humans and can thus beused as a marker to follow inheritance of the diseaseallele. In an informative family (in which one parentis heterozygous for both the disease allele and the DNA marker in a known chromosomal arrangementof alleles, and his or her mate does not have the samealleles of the DNA variant), the reliability of such amarker as a predictor of the disease in a fetus is related to the map distance between the DNA markerand the gene causing the disease.Imagine that a man affected with the disease(genotype Dd) is heterozygous for the V1and V2forms of the DNA variant, with form V1on the samechromosome as the D allele and form V2on the samechromosome as d. His wife is V3V3dd, where V3isanother allele of the DNA marker. Typing of the fetusby amniocentesis reveals that the fetus has the V2andV3variants of the DNA marker. How likely is it thatthe fetus has inherited the disease allele D if thedistance…
- In individuals affected by cystic fibrosis, salt crystals may appear afterperspiration dries up. In addition, the disease causes respiratory disorderswhich can be both debilitating and lethal. It occurs in individuals homozygousfor the recessive gene. Two normal parents had a daughter with thesymptoms of this disease, and a normal son who marries a normal womanwith an afflicted A test (salt concentration in perspiration of heterozygotes ishigher than normal) disclosed that both are indeed carriers of the gene. If thefirst child born to the mating in (b) was defective, what is the probability thatthe 2nd child would also be defective?Express answer in fraction form. The production of pigment in the outer layer of seedsof corn requires each of the three independently assorting genes A, C, and R to be represented by at leastone dominant allele, as specified in Problem 64. Thedominant allele Pr of a fourth independently assortinggene is required to convert the biochemical precursorinto a purple pigment, and its recessive allele pr makesthe pigment red. Plants that do not produce pigmenthave yellow seeds. Consider a cross of a strain of genotype A/A ; C/C ; R/R ; pr/pr with a strain of genotypea/a ; c/c ; r/r ; Pr/Pr.a. What are the phenotypes of the parents?b. What will be the phenotype of the F1?c. What phenotypes, and in what proportions, willappear in the progeny of a selfed F1?d. What progeny proportions do you predict from thetestcross of an F1?This problem examines possible biochemical explanations for variations of Mendel’s 9:3:3:1 ratio. Exceptwhere indicated, compounds 1, 2, 3, and 4 have different colors, as do mixtures of these compounds. Aand B are enzymes that catalyze the indicated steps ofthe pathway. Alleles A and B specify functional enzymes A and B, respectively; these are completelydominant to alleles a and b, which do not specify anyof the corresponding enzyme. If functional enzyme ispresent, assume that the compound to the left of thearrow is converted completely to the compound to theright of the arrow. For each pathway, what phenotypicratios would you expect among the progeny of a dihybrid cross of the form Aa Bb × Aa Bb?a. Independent pathwaysCompound 4Compound 2Compound 3Compound 1Enz AEnz Bb. Redundant pathwaysCompound 1 Compound 2Enz BEnz Ac. Sequential pathwayCompound 1 Compound 2 Compound 3Enz A Enz Bd. Enzymes A and B both needed to catalyze the reaction indicated.Compound 1 Compound 2
- Many genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus heterogeneity. How does locus heterogeneityconfound a pedigree analysis?Bloom syndrome is an autosomal recessive disease that exhibitshaploinsufficiency. A recent survey showed that people heterozygousfor mutations at the BLM locus are at increased risk of colon cancer.Suppose you are a genetic counselor. A young woman is referred to youwhose mother has Bloom syndrome; the young woman’s father has nofamily history of Bloom syndrome. The young woman asks whether sheis likely to experience any other health problems associated with herfamily history of Bloom syndrome. What advice would you give her?Unusual Gain-of-Function Alleles AreAlmost Always Dominant WHY?
- Null mutations are valuable genetic resources becausethey allow a researcher to determine what happens to anorganism in the complete absence of a particular protein. However, it is often not a trivial matter to determinewhether a mutation represents the null state of the gene.a. Geneticists sometimes use the following test forthe nullness of an allele in a diploid organism: If theabnormal phenotype seen in a homozygote for theallele is identical to that seen in a heterozygote(where one chromosome carries the allele in question and the homologous chromosome is known tobe completely deleted for the gene) then the alleleis null. What is the underlying rationale for thistest? What limitations might there be in interpreting such a result?b. Can you think of other methods to determinewhether an allele represents the null state of a particular gene?For Mendelian inheritance, the nuclear genotype (i.e., the allelesfound on chromosomes in the cell nucleus) directly influences anoffspring’s traits. In contrast, for non-Mendelian inheritance patterns, the offspring’s phenotype cannot be reliably predicted solelyfrom its genotype. For the following traits, what do you need toknow to predict the phenotypic outcome?A. Dwarfism due to a mutant Igf2 alleleB. Snail coiling directionC. Leber hereditary optic neuropathySix months pregnant, an expectant mother had a routineultrasound that showed that the limbs of the fetus wereunusually short. Her physician suspected that the babymight have a genetic form of dwarfism called achondroplasia,an autosomal dominant trait occurring with a frequency of about1 in 27,000 births. The parents were directed to a genetic counselorto discuss this diagnosis. In the conference, they learnedthat achondroplasia is caused by a mutant allele. Sometimes itis passed from one generation to another, but in 80 percent ofall cases it is the result of a spontaneous mutation that arisesin a gamete of one of the parents. They also learned that mostchildren with achondroplasia have normal intelligence and a normallife span. It has been suggested that prenatal genetic testing for achondroplasiabe made available and offered to all women. Wouldyou agree with this initiative? What ethical considerationswould you consider when evaluating the medical and societalconsequences of offering…