Factors influencing drug binding to plasma proteins and tissue reservoirs.  Distribution of drugs into special body compartments, e.g. role of the blood-brain barrier, placenta, etc.  Relationship of drug metabolism to excretion of drugs and termination of drug effects.

Explain the term first-pass eject or hepatic metabolism of the drug. What effect does first-pass have on drug bioavailability and activity?

Is the following statement true or false and explain why: The therapeutic index is a measure of how well a drug acts to relieve a medical condition.

If a hazardous drug on the REMs list is prescribed for a patient- the following is required to be done in order to dispense the drug, except: A) need to be enrolled in the REMs program B) patient must show they can afford the drug C) patient and physician agreement form needs to be completed D) patient will be counseled on the risks of the drug