Explain why citric acid (Krebs) cycle is a series of redox reactions. How many "turns" of the citric acid cycle would be required to completely oxidize one glucose molecule?

How many carbons from the original glucose molecule enter each round of the citric acid cycle?

Medical researchers are studying a patient with the newly discovered u LEKS metabolic syndrome, in which a genetic mutaton prevents NADH produced in the cytosol from being reoxidized by the electron transport chain. Suppose the following nutrient molecule is digested and metabolized by this patient under anaerobic conditions, e.g. during a sudden intense exertion: de HO-CH: -OH Он н. HO H OH How many ATP molecules will uttimately be produced by the catabolism of this molecule? Note: you can ussume the catabohism is as complete as it can be under the conditions given above. How many molecules of pyruvate will be produced during dycalysist How many maleoules of lactate will be produced

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27. Glycolysis and the citric acid cycle comprise two different sets of oxidation reactions. The reaction sequence for glycolysis is linear, whereas the reaction sequence for the citric acid cycle forms a circle. How does this difference in the arrangement of reactions influence the rate of these processes when an excess amount of a single intermediate is added?

1. (a) The reaction catalyzed by citrate synthase is the first step of the TCA cycle. In glycolysis, two key reactions to produce ATP occur because an unfavorable reaction is coupled to another reaction that is thermodynamically favorable. The reaction catalyzed by citrate synthase is similarly coupled to an unfavorable reaction in the TCA cycle. Write the unfavorable TCA reaction using structural formulas and write the key step that drives the two coupled reactions forward. What is the overall AG" of the coupled reactions? (b). K(yM) 25.7 Inhibitor Bromoacetyl-CoA ATP NADH 6800 8300 The inhibitor constants for three inhibitors of por- cine citrate synthase are summarized in the table on the right. The compounds were all determined to bind in the ac- tive site as competitive inhibitors of acetyl-CoA. Because they bind as competitive inhibitors, all three inhibitors must exhibit structural similarity to some part of acetyl-CoA. Look up in the textbook the structural formulas for…

For each step of the citric acid cycle, name the enzyme responsible for the chemical transformation that occurs and classify the enzyme type: Step 1. Step 2. Step 3. Step 4. Step 5. Step 6. Step 7. Step 8. i. oxidoreductase (oxidases, reductases, dehydrogenases) ii. transferase (transaminases, kinses) iii. hydrolase (lipases, proteases, nucleases, carbohydrases, phosphateses) iv. lyase (dehydratase, decarboxylase, deaminase, hydratase) v. isomerase (racemases, mutases) vi. ligase (synthetases, carboxylaces) Enzyme Name Enzyme Type

Why is it reasonable for excess NADH to negatively regulate the citric acid cycle?

Explain this krebs cycle

trace the position of the elctron as this glucose molecule proceeds through glycolsis and two turns of the citric acid cycle