Experiment 1: Synthesis of a Flavone This experiment will illustrate a multistep synthetic sequence and will constitute a three-step process. The first step of the synthesis will involve a simple benzoylation of 2-hydroxyacetophenone. The second step is a Baker-Venkataraman rearrangement to provide the ß-diketone 3, which upon treatment with acid leads to cyclization to form the target molecule 4. Note that the final compound is a heterocycle. Reaction Sequence: OH O Things to know: ● 1 2-Benzoyloxyacetophenone (2): . O Ph CI ● pyridine ● Acylation mechanism ● Büchner funnel-vacuum filtration Things to know: ● ● Ph 0 0 2 KOH heat recrystallization from MeOH (hot; cold) Structural Determination (m.p. IR, GC-MS and NMR) Dissolve 2-hydroxyacetophenone (1) (2.72 g, 20.0 mmol) in pyridine (5 mL), add benzoyl chloride (4.22 g, 30,0 mmol) by Pasteur pipette and then fit the flask with a calcium chloride drying tube. Swirl the flask and some heat will be evolved. Allow the reaction to stand for 20 min, or until no further heat is evolved, and then pour the entire contents of the flask into a mixture of 3% HC1¹ (-120 mL) and crushed ice (~40 g). Once all the ice has melted, collect the precipitated solids by vacuum filtration. Wash the product with ice-cold methanol (~5 mL) and then water (~5 ml). Dry at the pump for 20 min² and then recrystallize the crude product from methanol (~5 mL). Record a mp, IR, GC-MS and NMR spectrum on the product. Enolate & Acyl transfer mechanism Pyridine's role? ● Büchner funnel-vacuum filtration Structural Determination (Crude ¹H NMR and m.p.) OH OO 3 Ph ACOH MacBook Pro H₂SO4 o-Hydroxydibenzoylmethane (3): Dissolve 2 (2.40 g, 10 mmol) in pyridine (8 mL) in a 50 mL beaker and heat the solution to 50 °C on a steam bath. Add crushed KOH pellets (~0.85 g) and stir the resulting mixture with a glass rod. During this time a yellow precipitate of the potassium salt of 3 should form. Cool the mixture to room temperature and cautiously add 10% aqueous acetic acid solution (15 mL). Collect the product by suction filtration and dry at the pump for a few minutes. Record the yield, a ¹H NMR spectrum and the melting point. Use the crude product directly in the next step. Page < 1 This HCl solution should be made up immediately prior to the lab session in which it will be used. 2 Occasionally use a spatula to break up the filter cake to ensure thorough drying. O O Ph 4 1 > of 2

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You are performing an extraction and you begin with 0.70 g of crude starting material. At the conclusion of this exercise, you isolate 0.52 g of pure product. Calculate a percent recovery?

1. Complete the balanced molecular chemical equation for the reaction below. If no reaction occurs, write NR after the reaction arrow. Be sure to include the proper phases for all species within the reaction. Cu₂SO (aq) + Na₂PO₂(aq) → 2. 3. Complete the balanced molecular chemical equation for the reaction below. If no reaction occurs, write NR after the reaction arrow. Be sure to include the proper phases for all species within the reaction. Ba(CIO)₂(aq) + RbOH(aq) → Complete the balanced molecular chemical equation for the reaction below. If no reaction occurs, write NR after the reaction arrow. Be sure to include the proper phases for all species within the reaction. ZnCl₂(aq) + Hg₂(NO³)₂(aq) —

1) Explain the difference between a limiting and excess reagent. 2) A group of friend create an open-air campfire outside which burns wood. Carbon dioxide and water are produced from the burning.

1) The case study screenshot has been attached down below and the last sentence of the story is written down below and answer ques a,b,c  which is written down below as well step-by-step. The last sentence of the case study is to save money and had been reducing monitoring, inspections, and maintenance. a) Use the following reaction to determine how much of each product would be released if 42 000 kg (42 tonnes) of methyl isocyanate  reacted with excess water. This is the reaction methyl isocyanate + water -> 1,3-dimethyl urea + carbon dioxide  b) Create a list of mistakes that led to the Bhopal disaster; you should be able to find at least eight. Evaluate the list of mistakes. Identify the three mistakes you think were most significant in causing the disaster, and justify your choice in a short (2-3 senstence) statement.  c) What are some reasons it would have been safer to store the methyl isocyanate in smaller containers? Identify at least three reasons.

Can you answer all parts to this question  Theoretical yield of pinacolone in grams and moles show your calculations Final yield of pinacolone (grams and % yield) show your calculations

find theoretical yield of 102 mg of 4-tert-butylhexane equation is C10H18O please show work. table with info attached

Match each of the following hydrocarbons to the sum of the oefents of its balanced combustion reaction. For example, sum of coefficients of C2H4 + 3 O2 → 2 H2O + 2 CO2 is 1 + 3 + 2 + 2 = 7. If you are having trouble with this exercise, this video will help. 000 21 41 19 45 A 1. C7H8 2. C5H12 3. C6H8 4. C7H10

You begin the reaction with 6.5 mL of t-butyl alcohol (density= 0.775 grams/mL) and 15 mL of concentrated HCl (1.189 grams/mL, 38% HCl) in a distillation flask. Calculate the limiting reagent and the theroretical yield of the product (t-butyl chloride) for this reaction. (Hint:Your starting amount of HCl is 38% of the starting smount).