Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Pharmacology:
Provide examples of membrane transport in stroke, cell signaling (especially cell signaling) and homeostasis
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- Luke Marks is a 40-year-old male who was brought into ED by ambulance after he came off his motorcycle at 40km/hr after hitting a pothole in the road. The incident was called in by a bystander, an off-duty lifeguard, who helped to stabilise his c-spine by supporting his head (in a badly scratched helmet) and spoke to him until paramedics arrived. Handover from paramedics included: GCS 15, PERRLA, nil evidence of head injury despite a head strike, but Luke was unable to move his arms and legs and stated he had nil sensation in his legs and the sensation in his hands felt strange. The paramedics safely removed his helmet and safely secured a hard collar around his neck before transporting him to hospital. Luke reported pain of 8/10 in his cervical spine but nowhere else. His vital signs were as follows: RR 22, SpO2 98% RA, HR 59bpm, BP 125/63 mmHg, Temp 35.7 degrees. Paramedics administered 8mg IV ondansetron, 5mg s/c morphine and 250ml of NaCl (0.99%) en route. Luke has no significant…arrow_forwarddescribe in detail:how the Dopamine transporter (DAT)transporter works whether it is an active or passive transportera specific type of cell that it can be found in and why it is important in this cell typeconsequences for body function when this transporter type fails (due to a mutation that makes it non-functional)arrow_forwardCaffeine lowers the heart rate by increasing rates of depolarization at the SA node True False Nicotine raises the heart rate because it stimulates the activity of the sympathetic neurons in medulla oblongata True False The Frank-Starling Law of the Heart states that the force of heart contraction is directly proportional to the initial length of the muscle fiber, within optimal limits of length True False If the sarcomeres stretched beyond the optimal length, the force of contraction would go down, but that can potentially happen only during open heart surgery when the heart is not constrained by the pericardium, lungs, ribs and diaphragm. True False It is the Na+ channel-driven spontaneous depolarization that is affected by sympathetic and parasympathetic inputs to speed up or slow down the firing rate of the SA node and other conductive cells. True Falsearrow_forward
- Describe in detail the negative feedback mechanism that regulates blood pressre - Answers should include cardiovascular system response to a fall in BP Name and location of receptors Afferent pathway - how signal is sent to CNS (i.e. branch if ANS involved, name of neurotransmitter/hormone) Name and location of control centre in CNS Efferent pathway - how signal is sent to effectors Names and location of effectors How effectors bring about change in BP Link BP to equationarrow_forwardAntihypertensive treatment with calcium channel blockers (CCBs) is often offered to patients with stage 2 hypertension. Please describe the intracellular signaling events, mechanisms of action on blood vessels and important adverse effects of CCBs. In addition, describe considerations such as the age of a patient when prescribing a CCB at the first stage of antihypertensive therapy according to NICE guidelines.arrow_forwardRe-uptake results in: excitement of the neighboring neurons. more neurotransmitter molecules in the synaptic gap. less neurotransmitter molecules in the synaptic gap. unchanged amounts of neurotransmitter molecules in the synaptic gap.arrow_forward
- > S. ロ Guide & Lab Manual " An event causes a certain sequence of neurons to fire. In order to remember the event, the same sequence of neurons has to fire repeatedly. This causes a buildup of which ion in the neural pathway?" First Chapters of Saladin O sodium O calcium Free A&P Textbook BLACKBOARD Help O potassium O chloride A Moving to another question will save this response. « » 17 étv Aa MacBook Air 80 888 DD esc F1 F2 F3 F4 F5 F7 FB F9 F10 F11 @ 2# & 2 3 6. 7 8 Q W Y P tab A F K caps lock Z C V M shift control option command command optioarrow_forwardSubject: Neurophysiology The neuron for this experiment is in a bath with [K+] = 2 mM and [Na+] = 150 mM. Calculate the Nernst Equilibrium potential for each ion. What is your estimate for the gNa and for gK? If you are more comfortable, use PNa and PK. Remember, these values should be between 0 and 1. What is the resting membrane potential for this cell? Draw an action potential for this neuron in this solution. Keep in mind that this neuron is in unusual solutions. Label each axis and indicate inward and outward currents. Be absolutely certain to label the peak voltage and threshold for the AP!arrow_forwarddescribe in detail:how the Serotonin transporter works whether it is an active or passive transportera specific type of cell that it can be found in and why it is important in this cell typeconsequences for body function when this transporter type fails (due to a mutation that makes it non-functionalarrow_forward
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