14 C fill the blank with correct answer EUKARYOTIC RNA POLYMERASE TRANSCRIPTION FACTORSRather than just a sigma factor to recognize the promoter in conjunction with the polymerase core enzyme, the eukaryotic promoter isrecognized by a multi-subunit complex called transcription factorwhich is comprised of TATA-binding protein(TBP) and several TBP-associated factors (TAFS) wherein binding occurs independently of RNA Polymerase II. After this, twotranscription factors are needed. TFattaches to the TFI|D while TFto the nearby DNA,stabilizing the complex. TFIIF attaches to TFIID and TFIIB to allow docking of the RNA PolymeraseThe complex is still not ready tobegin transcription: two more factors are required. TFbinds TFIIF and RNA Polymerase II, and finally, TFattaches to RNA Polymerase II, providing a helicase activity needed to pry apart the two strands of DNA andallow the polymerase to read one of them. TFalso has another crucial enzymatic function: it is a serine kinase thatphosphorylates RŅA polymerase Il's carboxyl-terminal domain (CTD). The CTD contains numerous serines that, as they aresuccessively phosphorylated, form a (negatively charged) tail that aids in the separation of the RNẠP II and the TFIID/promoter.

Answer :: RNA polymerase extend or polymerise RNA. Sigma subunit of RNA polymerase binds to…

EUKARYOTIC RNA POLYMERASE TRANSCRIPTION FACTORS Rather than just a sigma factor to recognize the promoter in conjunction with the pol recognized by a multi-subunit complex called transcription factor (TBP) and several TBP-associated factors (TAFS) wherein binding occurs independent transcription factors are needed. TF attaches to the TFIID while stabilizing the complex. TFIIF attaches to TFIID and TFIIB to allow docking of the RNA begin transcription: two more factors are required. TF binds TFII attaches to RNA Polymerase lI, providing a helicase activity need allow the polymerase to read one of them. TF also has another c phosphorylates RŅA polymerase Il's carboxyl-terminal domain (CTD). The CTD conta successively phosphorylated, forma (negatively charged) tail that aids in the separatic

EUKARYOTIC RNA POLYMERASE TRANSCRIPTION FACTORS Rather than just a sigma factor to recognize the promoter in conjunction with the pol recognized by a multi-subunit complex called transcription factor (TBP) and several TBP-associated factors (TAFS) wherein binding occurs independent transcription factors are needed. TF attaches to the TFIID while stabilizing the complex. TFIIF attaches to TFIID and TFIIB to allow docking of the RNA begin transcription: two more factors are required. TF binds TFII attaches to RNA Polymerase lI, providing a helicase activity need allow the polymerase to read one of them. TF also has another c phosphorylates RŅA polymerase Il's carboxyl-terminal domain (CTD). The CTD conta successively phosphorylated, forma (negatively charged) tail that aids in the separatic

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 21QP: Transcriptional regulators are proteins that bind to promoters (the 5-flanking regions of genes) to...

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Identify the DNA elements and protein factors, #1-7, in the figure below that are involved in the initiation and elongation of transcription at a eukaryotic promoter of a gene TRANSCRIPTION ON RNA PROCESSING PefA A eukaryotic promoter commonly includes a TATA box (a nucleotide sequence TRANSLATION Ritoom containing TATA) about 25 nucleotides upstream from Nontemplate (coding) strand of DNA 7 Pupeptide 1 the transcriptional start point. Nontemplate (coding or sense) strand DNA TATAAAA ATATILTI 5 2 3 Start point 2 Several transcription TCCAA 3' 5' factors, one recognizing the TATA box, must bind 3' end to the DNA before RNA 4 polymerase Il can bind in the correct position and orientation. UCCA 3 5' 3' 3 Additional transcription GGTT factors (purple) bind to the DNA along with RNA 5' Direction of transcription polymerase II, forming the transcription initiation 3 complex. RNA polymerase Il then unwinds the DNA double helix, and RNA synthesis begins at the start point on the temple strand.…
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Search about transcription elongation factor P-TEFb with its relationship with CDK9 and RNA Pol II, what is the role of this particular transcription elongation factor compared with other general transcription factors and explain the mechanism on how eukaryotic transcription is controlled by the roles of this transcription factor (be specific on reaction or modification on RNA Pol II, which domain as you learn from the research article) and integrate the concept of chromatin remodeling in terms of packaging of DNA, and accessibility of the template for the RNA polymerase https://advances.sciencemag.org/content/6/50/eabc1450/tab-pdf