Enlarging chondrocytes within calcifying matrix Spongy bone formation in primary ossification center Formation of compact bone along the diaphysis Removal of spongy bone to form medullary cavity 24 Periosteum S Formation of spongy bone in the secondary ossification centers Bone sheath formation around shaft of cartilage rod Articular cartilage, which will remain throughout life to protect the ends of bones 2004 Spongy bone in the epiphysis Epiphyseal cartilage, where the bone will continue to elongate until adulthood 2007

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