Enkephalin binds best with :-a- delta ‘δ’ opiate receptorsb- muta ‘μ’ opiate receptorsc- kappa ‘κ’ opiate receptorsd- all opiate receptors with equal affinity

1. List the specific steps of beta-adrenergic receptor signaling through PKA activation. 2. What is the chromophore in rhodopsin? How does light absorption activate rhodopsin signaling? 3. How does the rhodopsin signaling pathway effector enzyme PDE affect levels of cGMP? At the molecular level, what is the result of the changed levels of cGMP and what response does this trigger? 4. What class of receptor is the insulin receptor (INSR)? When IRS1 is phosphorylated by the insulin receptor, what are the two signaling pathway branches that are activated? What physiological responses do these two branches regulate? 5. Both insulin and epinephrine regulate levels of D-glucose in the blood. How?

Name 5 drugs that have a high binding affinity towards the D2 receptor

Afatinib is an effective first-line treatment for patients with EGFR-mutant NSCLC. Research groups designed and synthesized afatinib analogs to increase the inhibitory effect against EGFR and VEGFR2/KDR kinases. Meo. OMe Br HN HN OMe Afatinib Compound I Compound II The researchers run a series of tests to explore the kinase inhibitory activity of Afatinib and Compound I with EGFR. They found the IC50 of Compound I is 3.6 nM and that of Afatinib is 1.6nM. a. Please briefly explain the effectiveness of Compound I compare to Afatinib based on the information given

If the DNA-Binding Domain on hormone receptors were mutated and unable to function properly, which of the following hormone receptors would be affected? Select one or more: O a Cytokine Receptor Ob. Steroid Receptor Family OC. Thyroid Receptor Family Od. Growth Factor Receptor O e. GPCR

What is the difference between nicotinic and muscarinic receptors on cell membranes? O bind different neurotransmitters one is an ion channel and one starts a 2nd messenger cascade one is alpha and the other is beta O all of the above are accurate

Which of the following changes would increase serotonin (5-HT) signaling between neurons? Select all that apply; partial point deduction for incorrect choices. O increase in serotonin synthesis O increase in the number of facilitating interneurons O decrease of serotonin receptors in the post-synaptic neuron inhibition of serotonin reuptake transporters O increase in activity of serotonin reuptake transporters O faulty transport and docking of synaptic vesicles decrease in serotonin synthesis O increase of serotonin receptors in the post-synaptic neuron