Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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Designing a Synthesis
Organic synthesis is a branch of chemical synthesis that involves the planned construction of organic compounds/molecules from smaller units that possess functional groups. Friedrich Wöhler was the first scientist who designed the synthesis of an organic…
Question

Draw the structure for the major organic product of each of the following reactions. 

The image depicts a multi-step organic synthesis reaction starting with an alkene substrate. The reaction is outlined as follows: 1. **BH₃, THF**: The first step involves the addition of borane (BH₃) in tetrahydrofuran (THF) to the alkene. This likely forms a trialkylborane intermediate through hydroboration. 2. **H₂O₂, H₂O, NaOH**: The second step involves oxidation using hydrogen peroxide (H₂O₂) in the presence of water and sodium hydroxide (NaOH). This converts the trialkylborane into an alcohol through an anti-Markovnikov hydration process. 3. **NaH**: In the third step, sodium hydride (NaH) is used. This is a strong base that typically deprotonates alcohols to form alkoxide ions. 4. **CH₃Br**: The fourth step involves a reaction with methyl bromide (CH₃Br). The alkoxide formed in the previous step likely acts as a nucleophile, displacing the bromide ion to form an ether. The reaction sequence summarizes a series of transformations that convert an alkene into a more complex organic molecule through hydroboration-oxidation, deprotonation, and etherification reactions.
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Transcribed Image Text:The image depicts a multi-step organic synthesis reaction starting with an alkene substrate. The reaction is outlined as follows: 1. **BH₃, THF**: The first step involves the addition of borane (BH₃) in tetrahydrofuran (THF) to the alkene. This likely forms a trialkylborane intermediate through hydroboration. 2. **H₂O₂, H₂O, NaOH**: The second step involves oxidation using hydrogen peroxide (H₂O₂) in the presence of water and sodium hydroxide (NaOH). This converts the trialkylborane into an alcohol through an anti-Markovnikov hydration process. 3. **NaH**: In the third step, sodium hydride (NaH) is used. This is a strong base that typically deprotonates alcohols to form alkoxide ions. 4. **CH₃Br**: The fourth step involves a reaction with methyl bromide (CH₃Br). The alkoxide formed in the previous step likely acts as a nucleophile, displacing the bromide ion to form an ether. The reaction sequence summarizes a series of transformations that convert an alkene into a more complex organic molecule through hydroboration-oxidation, deprotonation, and etherification reactions.
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