Dr. Frank, Ph.D. says that he is going to use CRISPR-Cas9 to cure a blood disorder that runs in his patient’s family. He says he will use CRISPR-Cas9 to inject the “healthy” allele into the patient’s thigh muscle. Will Dr. Frank's plan work? Why or why not?

Answered: Dr. Frank, Ph.D. says that he is going…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Dr. Frank, Ph.D. says that he is going to use CRISPR-Cas9 to cure a blood disorder that runs in his patient’s family. He says he will use CRISPR-Cas9 to inject the “healthy” allele into the patient’s thigh muscle. Will Dr. Frank's plan work? Why or why not?

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CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic immune mechanism exploited by bacteria and archaea to protect themselves from foreign nucleic acids. This system is used in vivo or in vitro for gene editing. The system can recognize and cut specific DNA sequences. The main obstacle of the CRISPR/Cas9 system is that it lacks an appropriate delivery carrier. To overcome this issue various viral carriers, cation lipids and nanoparticles are being employed.

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