Discuss/explain, in detail, the structural organization of the cellular component responsible for natural red uptake into the cell cytoplasm and into any cellular organelle.

Ran is a major player in the process of nucleocytoplasmic transport via the nuclear pore. Because net Ran movement simply follows a concentration gradient, what maintains the Ran gradient across the nuclear membrane? Options:   the concentration levels of cargo in the nucleus to be exported   GTP concentrations in the nucleus   the correct positioning of the GEF and GAP with respect to the nuclear envelope   the interaction of exportin and importin with their cognate substrates   none of the above

Which of the following changes to the microtubule binding protein, Tau, commonly occurs in Alzheimerâ s and other neurodegenerative diseases?   A Tau is hypo-phosphorylated and does not bind to microtubules to destabilize them.   B Tau levels are so low in the cell that they only bind to some microtubules.   C Tau is hyper-phosphorylated and does not bind to microtubules to stabilize them.   D Microtubules are hyper-phosphorylated and do not bind to Tau.

"In most animal cells, minus end-directed microtubule motors deliver their cargo to the periphery of the cell, whereas plus end-directed microtubule motors deliver their cargo to the interior of the cell", is true or false.

With reference to named examples, give a detailed account of the molecules and processes involved in trafficking soluble and membrane proteins from the Trans Golgi Network (TGN) to lysosomes. Include in your answer an explanation of how the trafficking machinery is recycled back, to the Trans Golgi Network in each case.

The studies of Palade and colleagues used pulse chase labeling with radioactively labeled amino acids and auto radiography to visualize the location of newly synthesized proteins in pancreatic acinar cells. These early experiments provided invaluable information on protein synthesis and intercompartmental transport. New methods have replaced these early approaches, but two basic requirements are still necessary for any assay to study this type of protein transport. What are they, and how do recent experimental approaches meet these criteria?

Well, the centriole is not present in the Pro-cariotic cell, nor is it in the permanent cell. So even if Amitosis can occur in procariotic cells, why not Amitosis occur in permanent cells? What is the thing that does not allow the permanent cell to divide normally in Amitosis like procariotic cell?

Draw out protein transport in the cell. Make sure to include all steps involved in transport through the secretory and endocytic pathways (including ER resident protein retrieval, transport to lysosome), transport in and out of the nucleus, and import into mitochondria. Include all details of vesicle transport (protein coat, SNARES, Rab) in your drawing