Discuss the mechanisms on how to stop the signal in synaptic transmission.

detail the steps for release, reception and recycling of neurotransmitters at the synaptic cleft

Explain the importance of neurotransmitter removal from the synaptic cleft and describe three removal mechanisms.

What is a post-synaptic potential and how is it caused? Describe the two types of post-synaptic potentials that can occur. Within this context, what does excitatory and inhibitory mean?

Selective serotonin reuptake inhibitors (SSRIs) are drugs that can alleviate symptoms of depression by blocking the reuptake of serotonin (5-HT) from the synaptic cleft, thereby increasing the amount of time that 5-HT remains active. Elevated levels of 5-HT within the synapse are associated with feelings of well-being; conversely, low levels of 5-HT are correlated with depressive symptoms. Recent studies have shown that SSRIs can also mediate their antidepressant effects by increasing brain levels of certain cytokines, including interferon gamma (IFNY). IFNY directly induces the expression of the protein p11 in neighboring neurons, which then interacts with 5-HTR4, a 5-HT transmembrane receptor. Figures 1 and 2 provide information about this interaction. 5-HTR4 protein (% of WT) expression CAMP levels (% change control) from 120T 100+ 80+ 60+ 40+ 20+ 0 MEM TOT Figure 1 5-HTR4 protein expression in plasma membrane-enriched fraction (MEM) of hippocampal lysate and in total hippocampal…

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Which of the following occurs during synaptic transmission? Select ALL that apply A) vesicles filled with neurotransmitter are released into the synapse B) an action potential travels through a neuron like a wave C) neurotransmitter binds to receptors on the sending neuron D) neurotransmitter binding to a receptor triggers the opening of an ion channel E) ions enter the receiving neuron's dendrites

Identify the multiple mechanisms by which a drug can be pro-ergic or anti-ergic at a synapse.

READ: They key to large-scale communication in the entire nervous system is the ability to pass nerve impulses on a small scale from one neuron to the next so that signals can be transmitted throughout the entire body. The junction between two neurons is called a synapse, and is the critical space that mediates the transfer of a signal from the presynaptic neuron (the sender) to the postsynaptic neuron (the receiver) or even an effector cell (like a gland or muscle cell.) You circled a synapse in Model 1. Synapses can be electrical or chemical. Electrical synapses transmit electrical signals via gap junctions. A channel protein connects the cytoplasm of two adjacent neurons so that ions can flow directly from one cell to another to pass on the signal. However, the most common type of synapse is a chemical synapse. These utilize chemical signals, called neurotransmitters, to transmit the signal across the synaptic cleft. This is a slower process, but allows for much greater precision…

Describe in detail synaptic termination by enxymes and by reuptake.