Discuss (as comprehensively but as concisely as possible) the role of protein folding in any (one) of the following diseases. Suggest an accepted appropriate treatment for the disease. Cite your references. (a) Alzheimer’s disease (b) Parkinson’s disease (c) Cystic fibrosis
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- Discuss (as comprehensively but as concisely as possible) the role of protein folding in any (one) of the following diseases. Suggest an accepted appropriate treatment for the disease. Cite your references.
(a) Alzheimer’s disease
(b) Parkinson’s disease
(c) Cystic fibrosis
(d) Gaucher’s disease
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Solved in 3 steps
- PKU is an abbreviation for what disorder? What are the symptoms of PKU? How can PKU be treated for a nearly normal life?Protein kinases (PTKS) are enzymes that regulate the biological activity of proteins by phosphorylation of specific amino acids, inducing a conformational change from an inactive to an active form of the protein. a) True b) FalseChoose the correct prosthetic group of the given protein. Choices: • Phosphate Nucleic acid Iron + Pigment • Zinc Iron • Lipid • Copper Pigment • Carbohydrate None 1. Collagen 2. Enkephalin 3. Albumin 4. Insulin 5. HDL 6. Chromatin 7. Cytochrome 8. Ovomucoid 9. Ceruloplasmin 10. Casein 11. ADH 12. Glutathione 13. Vitelline 14. Mucin 15. Carbonic Anhydrase
- Many bioactive compounds are derived from amino acids. This compound, found in trace amounts in mammalian brains and hypothesized to play a role as a neuromodulator or neurotransmitter, is derived from an amino acid through removal of the backbone carboxylic acid group. The amino acid from which it is derived must be: (Write out the entire name; Spelling matters, but case does not; Do not include L- or D- in the name; For acidic amino acids write the full name, e.g. “so-and-so acid”)Define the following terms: a. arginosuccinate b. Krebs bicycle c. N-acetylglutamate d. BH4 e. taurineWhat is Protein folding? Give at least 3 diseases that results from protein misfolding. Explain each. Can you give me a brief explanation about this question? Not less than 3 sentences.
- What does the acronym AGP represent?The melanocyte-stimulating hormone a-melanotropin has the following sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val In the one-letter code of amino acids, this sequence would be: SYSMEHFRWGKPV STSMGHFAWGKPV O SYSMDHFAWGKPV O SYSMEHFAWGLPVIdentify a disease or condition related to protein mis-folding. Which protein is misfolded? Is this a genetically inherited condition or is it transmissible?
- Briefly discuss how sickle cell mutation affects the protein.Which of the two structures, (Betaxolol) or (Sotalol) would be more contraindicated to treat a patient with hypertension and a history of depression, sleep disorders or psychosis? cr -o- CH2-CH-CH2-NH2-CH(CH3)2 -H2C-O-H2C-H2C- Он (Betaxolol) CH- -CH2-NH2-CH(CH3)2 OH Cr H3C-S-HN- (Sotalol)Identify the name of the amino acid and its group (aliphatic, aromatic, acidic, basic, hydroxylic, sulfur containing and amidic) and its classification (essential or non-essential). Format should be (Serine; Hydroxylic; Non-essential.)