Describe why PARP inhibitors are considered targeted therapies (affecting only cancer cells and not healthy cells)? Describe their mechanism of action.

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References Review View Help RCM Tell me what you want to do Editing v 12 A A BI U Av ... 2. Use the above photo to answer the following questions: a. What organism did you observe these cells in: b. What stain was used and what is it binding to causing this dark Header color: (stain) and bound to) c. What are the circles called in the cell staining dark: 100% lish (US) Text Predictions On A D home insert delete end prt sc 11 F12 F8 F9 8.

F. Written Response 1. If gene transcription is inhibited after fertilization, development past the two-cell stage does not take place in the mouse. However, in frog embryos, this treatment does not disrupt development until late cleavage. Explain this difference. 2. Twist transcription factors (TF) play key roles in embryonic development and are largely undetectable in normal adult tissues; however, their expression is reactivated during tumor progression and correlates with invasive and metastatic lesions. Transcription of the Twist gene is activated by Wnt signals and the Twist TF represses the gene for E-cadherin. Answer the following questions as briefly as possible, based on what was presented in class, not an internet search (complex answers that go beyond class material may lose points) a. Outline the steps from the Wnt signal to the E-cadherin gene (inclusive); e.g., A → B → C (with some clarifications such as "binds to", "activates", "represses") b. What are the normal…