Describe the role played by each enzyme, cofactor, andcoenzyme of the pyruvate dehydrogenase complex

Q: can you explain the catalytic mechanism of pyruvate dehydrogenase (complex)

A: Pyruvate dehydrogenase is a multimeric protein involved in the glycolytic pathway of the cell which…

Q: Briefly describe the biological rationale for each of the following allosteric phenomena: (a)…

A: Allosteric regulation occurs when an enzyme's activity is affected by binding of a small molecule.…

Q: Explain what will happen to reactions of pyruvate dehydrogenase complex when there is a deficiency…

A: Pyruvate dehydrogenase complex (PDC) is a complex formed by 3 enzymes that converts pyruvate into…

Q: Nonenzyme-bound FAD is a stronger oxidizing agent than NAD+ . How, then, can NAD+ oxidize the…

A: Pyruvate dehydrogenase complex is a multienzyme complex. It requires five cofactors, namely-TPP,…

Q: ist the inhibitors and activators of the Pyruvate Dehydrogenase Complex observed in most species?

A: Pyruvate dehydrogenase (PDH) complex is a multi-enzyme complex and catalyzes conversion of pyruvate…

Q: What are the three fates of the pyruvate and list which one is aerobic or anaerobic

A: Glucose is converted into pyruvate through the process of glycolysis. Since pyruvate is the major…

Q: How does an increase in the NADH/NAD+ratio affect the activity of pyruvate dehydrogenase?

A: The enzyme pyruvate (PDH) dehydrogenase is the major protein complex that helps to connect…

Q: What are the two most important carriers in one-carbonmetabolism? Give two examples of processes in…

A: These are the interlinking pathways that require methionine and folate.

Q: One of the consequences of ethanol addiction is fattyliver disease, an illness in which liver cells…

A: NADH or “nicotinamide adenine dinucleotide (NAD) + hydrogen (H)” is a reduced form of molecule NAD+…

Q: Most defects in pyruvate dehydrogenase complex are due to mutations in ______, so supplements with…

A: Introduction  Pyruvate dehydrogenase is a complex of enzymes that plays a critical role in aerobic…

Q: Which enzyme involved in the TCA cycle produces very similar outcomes compared to pyruvate…

A: The citric acid cycle is also known as the Krebs cycle or the tricarboxylic acid cycle. It is a…

Q: How does an increase in the NADH/NAD1 ratio affect the activity of pyruvate dehydrogenase?

A: Introduction: The citric acid cycle is a series of reactions that yield two carbon dioxide…

Q: What is the effect of an increase in the levels of glyceraldehyde-3-phosphate (G3P) on glycolysis.…

A: Amid the oxidation of glyceraldehyde 3-phosphate to 1,3-diphosphoglycerate, which is the as it were…

Q: Per molecule of pyruvate, how many molecules of CO2 are produced during acetyl-CoA formation and the…

A: Pyruvate,  a three carbon molecule is converted to acetyl CoA which is a two carbon molecule…

Q: Which precursors accumulate in patients with niacin deficiency. What effect does this deficiency…

A: Niacin is a precursor to nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine…

Q: What is the overall net reaction for the Pyruvate Dehydrogenase Complex? What enzyme(s) in the…

A: Cellular respiration in the aerobic organisms occurs through three process such as glycolysis,…

Q: Of the allosteric enzymes listed below, which are suppressed by NADH? Select all that apply. the…

A: Enzymes catalyse biochemical reactions. Substrate binds to the enzyme's active site and is converted…

Q: The reaction is reversible. Check all that apply. acetyl CoA lactate ethanol

A: “Since you have asked multiple questions, we will solve the first question for you. If you want any…

Q: Catabolism is oxidative in nature. How do pyruvate and beta-hydroxybutyrate compare with respect to…

A: Pyruvate formula C3H4O3 Redox level = 3×4 + 4×1 + 3×(-2) = 10 Beta-hydroxybutyrate formula C4H8O3…

Q: Briefly describe the biological rationale for each of the following allosteric phenomena: (a)…

A: Since you have posted a question with multiple sub-parts, we will solve the first three subparts for…

Q: Because dichloroacetate inhibits the enzyme pyruvatedehydrogenase kinase, this compound has been…

A: Pyruvate is an important product formed during the glycolysis stage of aerobic respiration. Pyruvate…

Q: Distinguish between catalytic coenzymes and stoichiometric coenzymes in the pyruvate dehydrogenase…

A: The Pyruvate dehydrogenase complex consists of five different coenzymes such as thiamine…

Q: What is the physiologic significance of pyruvate dehydrogenase complex?What's the biochemical basis…

A: Hi! As you have asked multiple questions, we are answering only the first two for you. If you need…

Q: Which of the following is true about comparing the α-ketoglutarate dehydrogenase complex and the…

A: The Citric Acid Cycle is the one where acetyl CoA acts as the substrate and undergoes a chain of…

Q: What three steps are included in the breakdown of pyruvate? Explain the importance of Acetyl Co A as…

A: Animal cells produce ATP by cellular respiration, whereas plant cells produce carbohydrates through…

Q: Briefly describe the role and location of each cofactor/coenzyme involved in the pyruvate…

A: Pyruvate is the end product of glycolysis. Under aerobic conditions, pyruvate is oxidised into…

Q: How does pyruvate from glycolysis get to the pyruvate dehydrogenase complex?

A: Pyruvate dehydrogenase complex : It is a complex of three enzymes that converts pyruvate into…

Q: In transamination processes, pyridoxal phosphate is an essential coenzyme. This coenzyme has…

A: Transamination is the reaction in which amino group from an amino acid is transferred to a keto acid…

Q: Deficiencies in the conversion of Pyruvate to Acetyl CoA may result in severe neurological…

A: Pyruvate Dehydrogenase (PDH) Deficiency

Q: A specialized lysine-linked co-enzyme often participates in the transfer of carbon fragments within…

A: The small non-protein organic molecules which work along with enzymes in various catalytic reactions…

Q: During Krebs cycle, the conversion of isocitrate to alpha-keto glutarate involves all of the…

A: Isocitrate to alpha-keto glutarate: Via enzyme isocitrate dehydrogenase

Q: Lactate dehydrogenase is one of the many enzymes that require NADH as coenzyme. It catalyzes the…

A: Formation of lactate catalyzed by lactate dehydrogenase. It is highly active muscle, there is…

Q: Which of the following conditions is most likely to lead to the activation of pyruvate…

A: The energy level and the availability of substrates inside the cell are the two factors that are…

Q: What are enzymatic markers within the mitochondria of oxidative metabolism

A: Mitochondria is the membrane-bound organelle. Mitochondria is the powerhouse of the cell. It plays a…

Metabolic pathways

Metabolism is defined as the group of life-supporting, enzyme-mediated chemical reactions in organisms. A metabolic pathway is a set of these chemical reactions that involve anabolism (synthesis of complex biomolecules) and catabolism (breakdown of biomolecules into small molecules) that occur inside a cell. Metabolites are the reacting substances, products, and intermediate substances of an enzymatic process that are altered by a series of chemical events catalyzed by enzymes.