Dapsone tablets, labelled 50 mg has an average tablet weight of 0.6509 g. 2.0g of powdered tablets reacted (see reaction below) with 26.05 mL of 0.0506N sodium nitrite (NaNO2) solution. Determine the amount of Dapsone as a percentage of the Label Strength (or Label Claim). Report your answer to 1 decimal place. Given: Dapsone molar mass, 248.302 g/mol Dapsone structure Reaction: Sodium nitrite (NaNO2) reacts with hydrochloric acid (HCl) to generate nitrous acid (HNO2). NaNO2 + HCl ® HNO2 + NaCl Nitrous acid (HNO2) then reacts with each amino group on Dapsone, and an indicator indicates the endpoint. R-NH2 (full structure shown above) + HNO2 + HCl ® R-N2Cl + 2H2O

Dapsone tablets, labelled 50 mg has an average tablet weight of 0.6509 g. 2.0g of powdered tablets reacted (see reaction below) with 26.05 mL of 0.0506N sodium nitrite (NaNO2) solution. Determine the amount of Dapsone as a percentage of the Label Strength (or Label Claim). Report your answer to 1 decimal place. Given: Dapsone molar mass, 248.302 g/mol Dapsone structure Reaction: Sodium nitrite (NaNO2) reacts with hydrochloric acid (HCl) to generate nitrous acid (HNO2). NaNO2 + HCl ® HNO2 + NaCl Nitrous acid (HNO2) then reacts with each amino group on Dapsone, and an indicator indicates the endpoint. R-NH2 (full structure shown above) + HNO2 + HCl ® R-N2Cl + 2H2O

Fundamentals Of Analytical Chemistry

9th Edition

ISBN:9781285640686

Author:Skoog

Publisher:Skoog

Chapter8: Sampling, Standardization, And Calibration

Section: Chapter Questions

Problem 8.1QAP

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