Past paper (d)The antibacterial activity of a number of penicillins was found to fit thefollowing QSAR equation (Figure Q13(d)):OXOXHHSCO2HLog(1/c) = -0.245 +1.720σ +5.673 (n=8, r=0.929)Figure Q13(d)What type of groups attached to the benzene ring give the highestantibacterial activity. Suggest at least two examples of substituentgroups, which have the right properties to show antibacterial activity.(7 marks)

(d) The given compound is Ampicillin.In the case of ampicillin, which is a penicillin derivative,…

Answered: (d) The antibacterial activity of a…

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter5: Alkenes: Bonding, Nomenclature, And Properties

Section: Chapter Questions

Problem 5.31P

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On the following page are three compounds, 1, 2, and 3, that have been investigated as anti-malarial candidates. Compound 1 is the "parent" molecule, and 2 and 3 are derivatives. Shown next to each molecule is (i) the enthalpy change when it binds to its target, and (ii) the dissociation constant for the molecule/target complex. Consider the structures and answer the following: AH = - 1.2 kcal/mol; Kp = 16 nM OH 1 HO AH = - 6.0 kcal/mol; Kp = 76 nM OH AH = - 5.5 kcal/mol; Kp = 0.5 nM OH 3 (i) What is the difference among 1, 2, and 3?
= (b) Calculate the pH of 0.0005 mol dm³ ethanoic acid when its pK₁ = 4.75 à CH₂COOH(aq) CH₂COO (aq) + Ht (aq) = K₁ pH =
▼ Part A Calculate AHx for the following reaction: Use the following reactions and given AH values: AHxn C7H16 (1) +1102(g) → 7CO₂(g) +8H₂O(g), -> C(s) + O2(g) → CO₂ (g), 2H₂(g) + O2(g) → 2H₂O(g), Express your answer to four significant figures in kilojoules. ▸ View Available Hint(s) VE ΑΣΦΑ Submit Previous Answers 7C(s) + 8H₂(g) → C₂H16 (1) Pearson Review I Constants I Periodic Table www ΔΗ ΔΗ ΔΗ kJ -4464.3 kJ -393.5 kJ -483.5 kJ
(Q1) What do you understand by the term selectivity, activity and stability in catalytic processes?
(Thanks for the help if you can break down the steps and provide drawings(needed) during the answer since i am trying to see if i have solved this in the right way not copy :)) Draw the heme environment in oxymyoglobin and explain how the geometric data for the attached oxygen molecule may be understood. Fe O (bond length) = 1.809 Å; O-O (bond length ) = 1.246 Å; Fe - O - O (bond angle) = 123 \deg
CO -110.5 -137.2 197.9 (g) CO2 -393.5 -394.4 213.6 (g) Hydrogen 130.58 g) Oxygen 02 205.0 (g) H20-285.83 -237.13 69.91 (1) The value of AS° for the catalytic hydrogenation of acetylene to ethene, C2H2 (g) + H2 (g) → C2H4 (g) is J/K• mol. Select one: O A. +18.6 O B. +112.0 O C. -112.0 O D. -18.6 E. +550.8
Draw the organic product expected from the reaction. Include all hydrogen atoms. Note that K, Cr, 0, is present in excess. H H H, SO, CH, CH,CH, OH + K,Cr,0,(aq) |
i. Which of the reactions given below is wrong? H3O*/H20 (A) MgBr + CO2 H2/Pt (B) CH;CH2CN CH;CH,NH2 heat NABH4 (C) HO OH/H20 (D) CI OH
82. The space shuttle Orbiter utilizes the oxidation of methylhy- drazine by dinitrogen tetroxide for propulsion: 4N₂H3CH3(1) + 5N₂O4 (1) 12H₂O(g) + 9N₂(g) + 4CO2(8) Calculate AH for this reaction. ▬▬▬▬▬▬▬▬▬▬
Find the AHrn for the following reaction: 2N29) + 502(9) → 2N,O5(9) given the following reactions and subsequent AH° values 2H2(9) + O2(9) → 2H,Ou) N½O5(9) + H2Ou → 2HNO3(1) AH° = -541.6 kJ AH° = -54.6 kJ %D N2(9) + 302(9) + H2(9) → 2HNO3(1) AH° -331.1 kJ
ion) 16-when a drop of starch solution was added to a brown solution of a now Substance (A) it turns dark blue, while when starch solution was Added to orange red solution of substance (B) it turns yellow. 1- The substance (A) is most likely to be? (a) lodine, I2 (b) Chlorine, Cl2 (C) bromine, Br2 a 2- The substance (B) is most likely to be? (a) lodine, I2 (b) Chlorine, Cl2 (C) bromine, Br2
Balance the following redox reactions, to their simplest form, by supplying the correct coefficients before each compound for #s 1-15. The unknown coefficients of the compounds should be whole numbers. Note: The reactions below are not yet balanced.

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