(D) Another repeating transformation is the reductive amination that shows up in the Schemes 3, 5 and 6. This takes Ar-NH₂ to Ar-N(CH3)2 with NaBH4/HCHO (formaldedyde). This provides the "rear" dipole that drives the nanocar. Show the mechanism for converting Ar-NH₂ → Ar-N(CH3)2 with two formaldehyde molecules and NaBH4. You will need to review your notes from lab5 in

(D) Another repeating transformation is the reductive amination that shows up in the Schemes 3, 5 and 6. This takes Ar-NH₂ to Ar-N(CH3)2 with NaBH4/HCHO (formaldedyde). This provides the "rear" dipole that drives the nanocar. Show the mechanism for converting Ar-NH₂ → Ar-N(CH3)2 with two formaldehyde molecules and NaBH4. You will need to review your notes from lab5 in

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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4. identify the structure of A and B in the following synthetic scheme: Write out complete reactions for each step, showing the structure of all reactants and products. (a) cyclohexanol +Na2Cr2O7/H2SO4, H2O -------> A (b) A + Et2NH/H2SO4 ----->B
(b) Consider the reaction of 1-bromobutane with a large excess of ammonia (NH3). Draw the reactants, the transition state, andthe products. Note that the initial product is the salt of an amine (RNH3+ Br - ), which is deprotonated by the excess ammonia to give the amine.
OH - NH, Br2/KOH →product; 1. (a-hydroxy amide) Product of this Hoffmann bromamide reaction is : OH (a) Ph – Ĉ-CH3 (Ъ) Ph — CHO (c) Ph- CH3 (d) Ph – CH2 -NH2 NO2
An acid anhydride can be formed under equilibrium conditions by reacting an ester with a carboxylic acid, as shown below. Reasonable yield is achieved if the equilibrium can be shifted by exploiting Le Châtelier's principle. -R" HO + + R ОН R' `OR" R `R' (a) Provide a complete, detailed mechanism for this reaction. (b) In general, the above equilibrium favors the reactants. However, if the ester that is used is the one shown here, then the equilibrium favors the products. Explain why. R' O.
9. (a) Under certain conditions, the reaction of 0.5 M 1-bromobutane with 1.0 M sodium methoxide forms 1-methoxybutane at a rate of 0.05 mol/L per second. What would be the rate if 0.1 M 1-bromobutane and 2.0 M NaOCH3 were used? (b) Consider the reaction of 1-bromobutane with a large excess of ammonia (NH3). Draw the reactants, the transition state, and the products. Note that the initial product is the salt of an amine (RNH* Br) which is deprotonated by the excess ammonia to give the amine. (c) Show another SN2 reaction using a different combination of an alkoxide and an alkyl bromide that also produces 1-methoxybutane.
If anhydrides react like acid chlorides with the nucleophiles, draw the products formed when each of the following nucleophiles reacts with benzoic anhydride [(C6H5CO)2O]: (a) CH3MgBr (2 equiv), then H2O; (b) LiAlH4, then H2O; (c) LiAlH[OC(CH3)3]3, then H2O.
Which of the following reactions will synthesize phenol from benzene? 1) HNO3 + H2SO4; 2) Fe, HCl; 3) NaNO2, HCl, 0-10 oC; 4) warm H2SO4 and H2O 1) HNO3 + H2SO4; 2) Fe, HCl; 3) NaNO2, HCl, 0-10 oC; 4) CuCN; 5) dilute acid and heat 1) Acetyl chloride & AlCl3; 2) bleach 1) Ph-N2+ + KI; 2) BrMgCH=CH2 in ether, followed by H3O+; 3) warm, conc'd KMnO4 1) Cl-CH(CH3)-CH2CH2CH3 + FeBr3; 2) hot, conc'd KMnO4
10) What is the major product? (A) (C) OH (B) H₂SO4 (cat) H₂O (D) НО. ОН .
(a) Tsomane and Nyiko were given a task of synthesising methylenecyclohexane 2. After a brief discussion with each other, Tsomane proposed Method A to synthesise 2 from cyclohexanone 1 while Nyiko proposed Method B that started from hydroxymethylcyclohexane 3. Each student believed that their proposed method is better than the other. (Scheme below) Ph THF A Ph Ph B H₂SO4 100 °C 3 OH (iii) In analysing both these methods, are there other possible alkene products other than methylenecyclohexane 2? Use mechanistic details to support your answer.
Complete the reaction scheme below. Show all reagents and intermediates. No reaction is a possible answer. 1) CH3CH2M9B CH3OH H+ (ехcess) но 2) H30*, H2O B A OCH3
(A) In the JK transformation, dilute HC1 (10%) was used to first deprotect/ unmask the acetal and ketal. Show the mechanism (use H3O+) for formation of the northern cyclohexene ring starting from the aldehyde and secondary amine. No need to show the mechanism of the acetal / ketal deprotection to the respective aldehyde and ketone. H -N-H CH3 CH3. CH31 CH3 K
3. Treatment of 1-phenyl-2-propenone with a strong base such as LDA does not yield an anion, even though it contains a hydrogen on the carbon atom next to the carbonyl group. Explain. (a) Ethyl pentanoate H Ethyl 2-methylbutanoate CH₂ . Which of the following compounds can be prepared by a malonic ester synthesis? Show the alkyl halide you would use in each case. 1-Phenyl-2-propenone (b) Ethyl 3-methylbutanoate (d) Ethyl 2,2-dimethylpropanoate