Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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3. Bioconjugate chemistry is a relatively new branch of science whereby
biological macromolecules, sometimes even from different classes, are
connected by a covalent bond or linkage. For example, a lipoprotein or
a glycolipid in which part of the molecule is a lipid and part protein or
is part carbohydrate and part protein can be considered a bioconjugate,
and there are many other examples. After a bioconjugation synthesis,
typically medicinal chemists use TLC to determine the extent of their
reaction where it can be used to separate the starting reactants from the
product (the bioconjugate). For example, consider the reaction of two
cysteine amino acids together in the formation of a disulfide bond and
the biological compound cystine (Eq. 3-2):
Cys-SH + Cys-SH
Cys-S-S-Cys (Cystine)
Eq. 3-2
Draw or sketch what the TLC pattern might look like where the
starting material is separated by the disulfide-bond-linked
dipeptide.
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Transcribed Image Text:3. Bioconjugate chemistry is a relatively new branch of science whereby biological macromolecules, sometimes even from different classes, are connected by a covalent bond or linkage. For example, a lipoprotein or a glycolipid in which part of the molecule is a lipid and part protein or is part carbohydrate and part protein can be considered a bioconjugate, and there are many other examples. After a bioconjugation synthesis, typically medicinal chemists use TLC to determine the extent of their reaction where it can be used to separate the starting reactants from the product (the bioconjugate). For example, consider the reaction of two cysteine amino acids together in the formation of a disulfide bond and the biological compound cystine (Eq. 3-2): Cys-SH + Cys-SH Cys-S-S-Cys (Cystine) Eq. 3-2 Draw or sketch what the TLC pattern might look like where the starting material is separated by the disulfide-bond-linked dipeptide.
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