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- For many years, targeted therapies for cancer treatment continue to be developed, however more and more patients are developing resistance to targeted therapies. Discuss one mechanism of resistance to targeted therapies for cancer and provide an example of how might creatively combat it using clinical concepts.Read the protocol to a cell adhesion assay experiment: Introduction- While there are many approaches that can be taken to study the "Hallmarks of Cancer", some of the most economical assays can be done using tissue culture models. While we will soon embark on a discussion of the perils of relving solely on cells grown in culture, we will find that the benefits of their usage comes in their "tractability": agonists and antagonists can be readily applied and removed from the cellular environment and behavioral reactions can be measured in a matter of hours or days. Thus, by using models such as tissue culture cells scientists can pose "bite-sized" experimental hypotheses that can be tested in well-controlled experiments in a relatively short amount of time. We will take advantage of these benefits this week by performing a simple assay of adhesive behavior that is commonly performed in the Cancer Biology world to ask basic questions about tumor cell behavior. Today we will visualize…Heterotypic interactions of tumor cells have been a fertile area for potential therapeutic interventions. Find a specific example of a drug/therapy that targets these interactions and explain the mechanism by which it treats cancer.
- Describe one chemotherapeutic approach that can be used to treat prostate cancer? Your answer should include information about the molecular processes and interactions which are at the core of the treatment strategyWhat are the potential applications of targeted nanomedicine delivery systems in improving the efficacy and reducing the side effects of cancer therapies?Discuss the role of antineoplastic therapy in the treatment of cancer
- Discuss how immunohistochemical techniques can identify and label the epithelial cells that may be useful in cancer biopsyBriefly explain how exploring the Enhanced Permeability and Retention model can improve cancertherapy.Explain the following characteristics of an ideal tumor marker • Specificity for a single type of cancer • High sensitivity and specificity for cancerous growth • Correlation of marker level with tumor size • Homogeneous (i.e., minimal post-translational modifications) • Short half-life in circulation
- Suppose there is a new drug targeting a type of cancer and the clinical trials are to be done with cancer patients, outline and explain the potential set-up of the evaluation for effect of the new drug. (Hint: The set-up should not jeopardize the patients receiving a placebo.)Using Excel, analyse your data and draw a graph of the percentage cell growth versus concentration of anti-cancer drug using the results obtained by the CVDE and AP methods. Comment on the results.The therapeutic index of an anti-cancer drug is reflective of which of the following(select all that apply)? A. Method by which drug is delivered B. The dosage at which side effects are minimal C. The number of patients receiving drug D. Selectivity over cancer cells vs normal cells E. The molecular target of the drug