Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter6: Safe Dosage Calculations
Section: Chapter Questions
Problem A.9CRQ
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Question
Will the amount of glycogen be higher or lower than normal or unchanged?
- Pyridoxal phosphate is covalently bonded to glycogen phosphorylase via a Schiff base to Lys 680. What effect would the mutation of Lys680Ala have on the breakdown of glycogen?(This notation means the following: K680 is the normal amino acid in this enzyme. It has been mutated to 680A.)
- Loss of the gene for the kinase that phosphorylates GSK3 on glycogen synthesis.
- Effect of the substrate analog below on glycogen synthesis.
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