Q 14.4: Mass spectrometry is ideally suited for analyzing pure compounds. However, when dealing with a mixture that contains several compounds, the compounds must first be separated from each other and then individually injected into the mass spectrometer to yield different spectra. This process has been greatly simplified by the advent of A gas chromatography - mass spectrometry (GC-MS) B C IR spectroscopy hydrogen deficiency index (HDI) D Electrospray ionization (ESI) E high resolution mass spectrometry

Q 14.4: Mass spectrometry is ideally suited for analyzing pure compounds. However, when dealing with a mixture that contains several compounds, the compounds must first be separated from each other and then individually injected into the mass spectrometer to yield different spectra. This process has been greatly simplified by the advent of A gas chromatography - mass spectrometry (GC-MS) B C IR spectroscopy hydrogen deficiency index (HDI) D Electrospray ionization (ESI) E high resolution mass spectrometry

Principles of Instrumental Analysis

7th Edition

ISBN:9781305577213

Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Chapter28: High-performance Liquid Chromatography

Section: Chapter Questions

Problem 28.17QAP: Mass spectrometry is an extremely versatile detection system for GC. However, interfacing an HPLC...

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Mass spectrometry is an extremely versatile detection system for GC. However, interfacing an HPLC system to a mass spectrometer is a much more difficult task. Describe the major reasons why it is more difficult to combine HPLC with mass spectrometry than it is to combine GC with mass spectrometry.
Q.1. Predict the relative intensity of the M, M+1, and M+2 peaks for a low resolution mass spectrum of a compound with molecular formula, C6H13Br. The natural abundances of the select isotopes are given below. 35 Cl: 75.8% 79Br: 50.5% 12C: 98.89% 37Cl: 24.2% (The ratio is almost 3:1) 81Br: 49.5% (The ratio is almost 1:1) 13C: 1.11%
Identify the following in the given IR Mass spectrum. Compound 1 Mass Spectroscopy: Interpretation of peaks: Compound 1 Mass Spectroscopy: MASS SPECTRUM 100 80 60 40 20 0.0- 10 20 30 40 50 60 70 m/z Interpretation of peaks: Rel. Intensity
Mixtures can be quantified using UV-Vis spectroscopy. True False
Define mass spectroscopy and the underlying principle/background of its method for characterizing samples.
Explain why an internal standard is required during sample preparation in quantitative analysis when using atomic spectroscopy?
a) How does mass spectrometry identify organic compounds? b) Describe the use and function of Quadrupole Analyzers ? c) One of the ionization sources for atomic mass spectrometry (MS) is Inductively Coupled Plasma (ICP). Explain the need for an interface in the ICPMS instrument and how can it be achieved.
5. Use the mass spectrum to propose a molecular formula for the compound. Show your work. 100 80 60 (M)* m/z = 87 intensity = 35% 40 (M+1) m/z = 88 intensity = 2% 20 0.0 0.0 20 40 60 80 100 m/z Rel. Intensity
23. Consider the mass spectrum of hexane. Relative Intensity 100 80 60 40 20 O a. b. C. d. e. f. g. 10 MS-NW-5505 50 m/z Label the [M] peak. What is the value of m/z associated with this peak? 20 30 40 60 70 What is the mass of a hexane molecule that contains six ¹2℃ atoms (¹2CH3-¹2CH₂-¹2CH₂-¹2CH₂-¹2CH₂-¹2CH3)? Does this fit with the m/z value reported in part a of this question? 80 Draw a picture, like the one of "all ¹²C hexane" above, of a molecule that can account for the existence of a peak at m/z = 87 in the mass spectrum of hexane. (Check your work.) There are actually three acceptable answers to the previous question because there are three unique locations in a hexane molecule to replace a ¹2C with a ¹3C. If you have not already done so, draw the other two acceptable answers to the previous question. The peak at m/z = 87 is called the [M+1]* peak. Construct an explanation for this name. Use your periodic table to calculate the weight, in grams, of 1 mole of hexane to four…
2. Let's look at the electron-ionization Rel. Intensity 100 80 60 40 20 0.0 10 Ethanol, ¹2C₂ ¹H6 ¹60 (mass = 46) 20 a. Identify the molecular ion pick. mass spectra of ethanol (El-MS) b. Identify the base pick. Ethanol MASS SPECTRUM 30 m/z C. What type of species are detected by the detector? 40 50
Determine the isotopic peak scheme for [ReCl]+ fragment in the mass spectrum? 185Re: %37 ; 187Re: %63; 35Cl: %76; 37Cl: %24
3. Dibromocholestanol was analyzed by mass spectrometry using the electron impact (El) ionization technique. The following peaks were observed with relative intensities of ~1:2:1 Low Resolution MS (EI) m/z= 544, 546, and 548 Identify the peaks in the molecular ion pattern and which combination of isotopes produces these peaks: [M]: m/z = formula: [M+2]+: m/z = [M+4]+ : m/z = formula: formula: