Changes affecting tumor suppressors generally require _____ alleles to be affected in order to trigger transformation. one five or more two zero
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Question:-
Changes affecting tumor suppressors generally require _____ alleles to be affected in order to trigger transformation.
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one |
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five or more |
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two |
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zero |
Step by step
Solved in 3 steps
- You are looking at the results of a western blot from the lysates of cells harvested from a suspected breast cancer tumor and you see that there is an increased expression of INK4-p16, you suspect that this will______________? Group of answer choices Increase S to G2 phase transition Initiate a cell cycle arrest in G1 Block M to G1 phase transition Promote tumorigenesisCancer is a genetic disease. To provide evidence that you understand cancer genes are altered in both sporadic (somatic) and inherited cancers, match the beginning and end of the sentences below to give correct statements. NOTE: there is one extra, redundant answer, do not use it. This question has partial credit, so you will still be awarded some marks even if all of your sentences are not correct. Prompts Gain of function Oncogenes Mutated forms of proto-oncogenes Examples of oncogenes Loss of function. Examples of tumor suppressor genes Tumor suppressor genes Inherited cancer The Knudson's 2-hit hypothesis Both inherited and sporadic cancers Submitted Answers Choose a match Choose a match Choose a match Choose a match. Choose a match. Choose a match Choose a match. Choose a match. Choose a match Choose a match. ▼ ▼ ▼ O protect cells from uncontrolled proliferation are; CMYC, KRAS & ErBb2 is seen in oncogenes, leading to cancer. involve Tumor suppressor genes are not involved in…Determine if the gene on the left is a proto-oncogene or tumor suppressor. APC p53 Ras [Choose] [Choose] Tumor suppressor Proto-oncogene [Choose]
- You have two patients. Both patients have very low levels of P53 protein. Patient #1 also has very low levels of MDM2 protein; patient #2 has very high levels of MDM2. For each patient briefly describe (briefly justify your answers); Which of the two genes are mutated?P53 or MDM2? Is this an oncogenic or tumor suppressor mutation? Would treatment of the patient with Nutlins be appropriate?"In the cellular regulatory pathways that control cell growth and proliferation, the products of oncogenes are stimulatory components and the products of tumor suppressor genes are inhibitory components" is true or false.p53 is a gene / protein often associated with cancer. Why? What does p53 do? What kind of gene is it? Is it associated more with any one particular type of cancer or all cancers? Tell me more about p53, but please do not exceed one typed page.
- are changes to the order of nucleotides in a segment of DNA that codes for a protein. Proto-oncogenes Tumor suppressor genes Gene mutations Negative regulatorsduring tumor progression, additional mutations occur within multiple cells of a tumor population, leading to multiple different clones of cells within that tumor. Some) but not all) clones may eventually metastasize, depending on the number and type of mutations that occur in those clones. true falseWhy is it harder to develop a drug that targets a tumor suppressor gene compared to an oncogene (limit 3-4 sentences)?
- L A Moving to another question will save this response. Question 5 Select the correct statements 0 An oncogene is a cancer producing gene A proto-oncogene is only found in cancer cells Tumor suppressor genes are genes whose normal products inhibit cell division A proto-oncogene is a normal cellular gene that has the potential to become an oncogene A Moving to another question will save this response.Of the following choices a loss of function mutation would most lukely contribute to cancer onset if the mutant gene codes for a : telomerase tumor suppressor protein ATP synthesis enzyme RNS binding proteinTumor suppressor genes and oncogenes are implicated in carcinogenesis. However, one can predict whether a gene potentially encodes for a protein that influences carcinogenesis by examining their mutational profile. You sequence the genome of 4 cancers and identify 3 genes of interest. Which of the following genes has the best potential to an oncogene? Tumor 1 Tumor 2 Tumor 3 Tumor 4 Gene A S24F, N465T R33T T345S, G366R P367E, P368Y Gene B S34R, F360I S34R V254I S34E, T67Y Gene C S24F, I322E C255I, E344D S34E, P367E