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CD62L CCR7 CXCR5 S1P1 Naïve T and B cells would not home properly to the HEV. Naïve T cells would not home properly to the paracortex. Activated B cells would not home properly to the follicle-paracortex border. The animal would be immunocompromised and not be able to develop adaptive immune responses unless compensated by other chemokines. Naïve B cells would not home properly to the follicle. The animal would be partially, but significantly, immunocompromised because it would not be able to develop T cell-dependent antibody responses unless compensated by other chemokines. Naïve T and B cells, effector T and B cells, and effector memory T and B cells would not be able to leave the lymph node. Answer Bank The animal would be significantly immunocompromised but may be able to compensate with some innate immunity and splenic T cell and B cell activity. The animal would be immunocompromised unless compensated by other egress regulators and extralymphoid immune cell activity.

CD62L CCR7 CXCR5 S1P1 Naïve T and B cells would not home properly to the HEV. Naïve T cells would not home properly to the paracortex. Activated B cells would not home properly to the follicle-paracortex border. The animal would be immunocompromised and not be able to develop adaptive immune responses unless compensated by other chemokines. Naïve B cells would not home properly to the follicle. The animal would be partially, but significantly, immunocompromised because it would not be able to develop T cell-dependent antibody responses unless compensated by other chemokines. Naïve T and B cells, effector T and B cells, and effector memory T and B cells would not be able to leave the lymph node. Answer Bank The animal would be significantly immunocompromised but may be able to compensate with some innate immunity and splenic T cell and B cell activity. The animal would be immunocompromised unless compensated by other egress regulators and extralymphoid immune cell activity.

Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter17: Genes And The Immune System
Section: Chapter Questions
Problem 31QP
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CD62L CCR7 CXCR5 S1P1 Naïve T and B cells would not home properly to the HEV. Naïve T cells would not home properly to the paracortex. Activated B cells would not home properly to the follicle-paracortex border. The animal would be immunocompromised and not be able to develop adaptive immune responses unless compensated by other chemokines. Naïve B cells would not home properly to the follicle. The animal would be partially, but significantly, immunocompromised because it would not be able to develop T cell-dependent antibody responses unless compensated by other chemokines. Naïve T and B cells, effector T and B cells, and effector memory T and B cells would not be able to leave the lymph node. Answer Bank The animal would be significantly immunocompromised but may be able to compensate with some innate immunity and splenic T cell and B cell activity. The animal would be immunocompromised unless compensated by other egress regulators and extralymphoid immune cell activity.
Transcribed Image Text:CD62L CCR7 CXCR5 S1P1 Naïve T and B cells would not home properly to the HEV. Naïve T cells would not home properly to the paracortex. Activated B cells would not home properly to the follicle-paracortex border. The animal would be immunocompromised and not be able to develop adaptive immune responses unless compensated by other chemokines. Naïve B cells would not home properly to the follicle. The animal would be partially, but significantly, immunocompromised because it would not be able to develop T cell-dependent antibody responses unless compensated by other chemokines. Naïve T and B cells, effector T and B cells, and effector memory T and B cells would not be able to leave the lymph node. Answer Bank The animal would be significantly immunocompromised but may be able to compensate with some innate immunity and splenic T cell and B cell activity. The animal would be immunocompromised unless compensated by other egress regulators and extralymphoid immune cell activity.
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