Carboxypeptidase, which sequentially removes carboxyl-terminal amino acid residues from its peptide substrates, is a single polypeptide of 307 amino acids. The two essential catalytic groups in the active site arefurnished by Arg 145 and Glu 270 .(a) If the carboxypeptidase chain were a perfect α helix, how far apart (in Å) would Arg 145 and Glu 270 be? (b) Explain how the two amino acid residues can catalyze a reaction occurring in the space of a few angstroms

Enzymes are a group of proteins that acts as biological catalysts to accelerate the various chemical…

Answered: Carboxypeptidase, which sequentially…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Carboxypeptidase, which sequentially removes carboxyl-terminal amino acid residues from its peptide substrates, is a single polypeptide of 307 amino acids. The two essential catalytic groups in the active site are
furnished by Arg ¹⁴⁵ and Glu ²⁷⁰ .
(a) If the carboxypeptidase chain were a perfect α helix, how far apart (in Å) would Arg ¹⁴⁵ and Glu²⁷⁰ be?
(b) Explain how the two amino acid residues can catalyze a reaction occurring in the space of a few angstroms

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