Calcium is an important intracellular messenger that results in various cellular responses. In muscle cells, calcium is sequestered within a specialized organelle called the sarcoplasmic reticulum (SR). Release of calcium causes muscle contraction, and the calcium must be re-uptaken into the SR via the sarcoplasmic reticulum Ca²+ ATPase (SERCA) before muscle cells can relax. Determine how many calcium ions can be pumped into the SR lumen from the cytosol per ATP hydrolysis via SERCA under the following conditions: [Ca2+] cytosol = 4.85 μM [Ca2+]lumen 12.8 μM = cytosol -90.0 mV lumen 0.00 mV What is the AG for the unfavorable transport of calcium (use 3 significant figures)? 14.9 kJ/mol How many ions can be transported per ATP hydrolysis (Use a whole number) (assume AG = AG°)? 1

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Chapter1: Chemical Foundations
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Calcium is an important intracellular messenger that results in
various cellular responses. In muscle cells, calcium is sequestered
within a specialized organelle called the sarcoplasmic reticulum
(SR). Release of calcium causes muscle contraction, and the calcium
must be re-uptaken into the SR via the sarcoplasmic reticulum Ca²+
ATPase (SERCA) before muscle cells can relax. Determine how
many calcium ions can be pumped into the SR lumen from the
cytosol per ATP hydrolysis via SERCA under the following
conditions:
[Ca2+] cytosol = 4.85 μM
[Ca2+]lumen 12.8 μM
=
cytosol -90.0 mV
lumen 0.00 mV
What is the AG for the unfavorable transport of calcium (use 3
significant figures)? 14.9
kJ/mol
How many ions can be transported per ATP hydrolysis (Use a whole
number) (assume AG = AG°)? 1
Transcribed Image Text:Calcium is an important intracellular messenger that results in various cellular responses. In muscle cells, calcium is sequestered within a specialized organelle called the sarcoplasmic reticulum (SR). Release of calcium causes muscle contraction, and the calcium must be re-uptaken into the SR via the sarcoplasmic reticulum Ca²+ ATPase (SERCA) before muscle cells can relax. Determine how many calcium ions can be pumped into the SR lumen from the cytosol per ATP hydrolysis via SERCA under the following conditions: [Ca2+] cytosol = 4.85 μM [Ca2+]lumen 12.8 μM = cytosol -90.0 mV lumen 0.00 mV What is the AG for the unfavorable transport of calcium (use 3 significant figures)? 14.9 kJ/mol How many ions can be transported per ATP hydrolysis (Use a whole number) (assume AG = AG°)? 1
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