Briefly outline the events that control the progression of cells through the G1/S checkpoint in the cell cycle.

Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Briefly outline the events that control the progression of cells through
the G1/S checkpoint in the cell cycle.

Expert Solution
Step 1

A checkpoint is described as a level at which cell examines diverse inner and outside elements and makes a decision whether or not or now no longer pass ahead with division.

Most important checkpoints are: G1 checkpoint at G1/S transition, G2 checkpoint at G2/M transition and spindle checkpoint at metaphase to anaphase transition.

 

 

Step 2

The most critical checkpoint in the cell division at which cell choose whether to divide or not is G1 checkpoint. Once the cell passes this checkpoint and enters S phase, it becomes committed to the division process. Cell barrs all troubles inclusive of DNA damage or replication mistakes and retain the cell cycle and produces daughter cells. Some factors like size, nutrition, molecular signals and DNA integrity affects the progression of the cell through G1 checkpoint.

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