Briefly describe the significance of the balance between coagulation and fibrinolytic systems. Why heparin is a very powerful anticoagulant?

Name the enzyme that catalyses the formation of carbonic acid in erythtocytes.

Describe the function of Vitamin K in coagulation.

It is known that heparin acts by increasing the activity of antithrombin, causing a conformational change. LMWHs inhibit mainly factor Xa. Although low doses of heparin act primarily by neutralizing factor Xa, at high doses it prevents thrombin-induced platelet activation and prolongs bleeding time. What are major clinical benefits using heparin or LMWHs?

Outline or briefly describe the sequence of events that leads to blood coagulation.

Describe the conclusions that can be drawn from a ʺCBC with diffʺ that comes back showing (a) elevated neutrophils, (b) with elevated eosinophils.

The intrinsic and extrinsic pathways merge with the formation of: fibrin fibrinogen prothrombin prothrombinase thrombin

Describe the erythrocyte maturation sequence

Know the central role of thrombin and list the highlighted roles of thrombin Describe how coagulation cascade is accelerated and inhibited and describe the mechanism of action of the endogenous anticoagulants: TFPI, ATIII, Heparin, Thrombomodulin, APC

Describe the platelet receptor-ligand interaction and its biological outcome