Br COзн Et,N DBU CH;SO2 phenylacetic acid CH;SO2 х rofecoxib

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A: Interpretation - To explain the biosynthesis pathway of caffeine to Theobromine in detail -…

Q: What 1° amine and carbonyl compound are needed to prepare each imine?

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Q: Explain Alkylation of a Diethyl Malonate Derivative ?

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Q: Illustrate the Separation of cyclohexanamine and cyclohexanol by an extraction procedure ?

A: Separation of cyclohexanamine and cyclohexanol by an extraction procedure.

Q: 16.51 Propose a plausible mechanism for the following transformation: Heat

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Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.