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B. For a mutant in which the T-R equilibrium is shifted toward the T state, what type of change would you expect in P50? (Would the P50 for the mutant be higher or lower than normal HbA?) Does that mean O2 affinity of mutant is higher or lower than normal? Sketch a normal HbA binding curve (sigmoid) and then sketch the curve you would expect for a mutant with T-R equilibrium shifted toward the T state. UCR BCH 110A – Discussion 4 --Practice Problems: Fetal Hemoglobin and Enzymes Introduction

B. For a mutant in which the T-R equilibrium is shifted toward the T state, what type of change would you expect in P50? (Would the P50 for the mutant be higher or lower than normal HbA?) Does that mean O2 affinity of mutant is higher or lower than normal? Sketch a normal HbA binding curve (sigmoid) and then sketch the curve you would expect for a mutant with T-R equilibrium shifted toward the T state. UCR BCH 110A – Discussion 4 --Practice Problems: Fetal Hemoglobin and Enzymes Introduction

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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B. For a mutant in which the T-R equilibrium is shifted toward the T state, what type of change would you expect in P50? (Would the P50 for the mutant be higher or lower than normal HbA?) Does that mean O2 affinity of mutant is higher or lower than normal? Sketch a normal HbA binding curve (sigmoid) and then sketch the curve you would expect for a mutant with T-R equilibrium shifted toward the T state. UCR BCH 110A – Discussion 4 --Practice Problems: Fetal Hemoglobin and Enzymes Introduction
Transcribed Image Text:B. For a mutant in which the T-R equilibrium is shifted toward the T state, what type of change would you expect in P50? (Would the P50 for the mutant be higher or lower than normal HbA?) Does that mean O2 affinity of mutant is higher or lower than normal? Sketch a normal HbA binding curve (sigmoid) and then sketch the curve you would expect for a mutant with T-R equilibrium shifted toward the T state. UCR BCH 110A – Discussion 4 --Practice Problems: Fetal Hemoglobin and Enzymes Introduction
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