Write a brief report comparing the pharmacokinetic profile of two different drugs in different administration routes (drug X and drug Y; one of them should be in IV form). (for example oral amoxicillin and IV tigecycline; topical diclofenac and IV paracetamol etc) In your assignment, the following info should be included (if applicable): the elimination half-life of each drug • peak concentration of each drug volume of distribution of each drug the plasma protein binding profile of each drug bioavailability of each drug How are drugs X and Y metabolized? How are drugs X and Y excreted? Total systemic clearance of each drug The steady-state concentration of each drug Do drugs X and Y undergo first-pass effect? • the daily dose of each drug for a 70kg male patient (assume that the patient does not have co-morbidities) • If drug X is given as IV infusion, what should the maintenance dose be? If drug Y is given as IV infusion, what should the maintenance dose be? • If drug X is given as IV infusion, what should the rate of infusion be? Fast, slow? Explain the reason. • If drug Y is given as IV infusion, what should the rate of infusion be? Fast, slow? Explain the reason. • Is there any condition or disease state in which dose adjustment of each drug is required? (such as renal disease or liver disease) This activity is intended to build your experience with accessing the primary pharmacokinetics data and identifying relevant reports of altered drug ADME processes. Page limit will be a maximum of 2 pages with Times New Roman 12. There will be one space between the lines.

Select ready-made drugs in different dosage forms from the variety of drugs and classify them according to all classification signs (Annex 1). Write down the results into table 1. Ready-made drugs classification results No Name of ready- made drug By the By the By the applica-tion toxicity By physical By dates of By state of and chemical expira-tion aggregation and pharmaco- logical activity method properties dosage form Example Norfloxacine Antimicro-bial For internal General list Require light- Solid (tablets) Storage period is 3 agent use protection years 1 2 3 4 5 Classification

Granisetron HCl is indicated for the prevention of nausea and vomiting associated with chemotherapy and radiotherapy. Your 90 kg has been prescribed granisetron HCl at the dose recommended on the drug label below. Determine what volume of this medication you will administer at each dose.   Indicate the quantity and unit of measure where specified. Quantity: Unit:

Mrs Banks, one of your regular patients comes in with a new prescription.  She has been taking digoxin and furosemide for several years now.  She has recently sprained her ankle which is very painful and has also been preventing her from sleeping properly.  She has seen a GP at an emergency appointment and has been started on nitrazepam and co-codamol 30/500. consider the suitability of each drug and dosage.