Write a brief report comparing the pharmacokinetic profile of two different drugs in different administration routes (drug X and drug Y; one of them should be in IV form). (for example oral amoxicillin and IV tigecycline; topical diclofenac and IV paracetamol etc) In your assignment, the following info should be included (if applicable): the elimination half-life of each drug • peak concentration of each drug volume of distribution of each drug the plasma protein binding profile of each drug bioavailability of each drug How are drugs X and Y metabolized? How are drugs X and Y excreted? Total systemic clearance of each drug The steady-state concentration of each drug Do drugs X and Y undergo first-pass effect? • the daily dose of each drug for a 70kg male patient (assume that the patient does not have co-morbidities) • If drug X is given as IV infusion, what should the maintenance dose be? If drug Y is given as IV infusion, what should the maintenance dose be? • If drug X is given as IV infusion, what should the rate of infusion be? Fast, slow? Explain the reason. • If drug Y is given as IV infusion, what should the rate of infusion be? Fast, slow? Explain the reason. • Is there any condition or disease state in which dose adjustment of each drug is required? (such as renal disease or liver disease) This activity is intended to build your experience with accessing the primary pharmacokinetics data and identifying relevant reports of altered drug ADME processes. Page limit will be a maximum of 2 pages with Times New Roman 12. There will be one space between the lines.
Write a brief report comparing the pharmacokinetic profile of two different drugs in different administration routes (drug X and drug Y; one of them should be in IV form). (for example oral amoxicillin and IV tigecycline; topical diclofenac and IV paracetamol etc) In your assignment, the following info should be included (if applicable): the elimination half-life of each drug • peak concentration of each drug volume of distribution of each drug the plasma protein binding profile of each drug bioavailability of each drug How are drugs X and Y metabolized? How are drugs X and Y excreted? Total systemic clearance of each drug The steady-state concentration of each drug Do drugs X and Y undergo first-pass effect? • the daily dose of each drug for a 70kg male patient (assume that the patient does not have co-morbidities) • If drug X is given as IV infusion, what should the maintenance dose be? If drug Y is given as IV infusion, what should the maintenance dose be? • If drug X is given as IV infusion, what should the rate of infusion be? Fast, slow? Explain the reason. • If drug Y is given as IV infusion, what should the rate of infusion be? Fast, slow? Explain the reason. • Is there any condition or disease state in which dose adjustment of each drug is required? (such as renal disease or liver disease) This activity is intended to build your experience with accessing the primary pharmacokinetics data and identifying relevant reports of altered drug ADME processes. Page limit will be a maximum of 2 pages with Times New Roman 12. There will be one space between the lines.
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Transcribed Image Text:Write a brief report comparing the pharmacokinetic profile of two different drugs in different
administration routes (drug X and drug Y; one of them should be in IV form).
(for example oral amoxicillin and IV tigecycline; topical diclofenac and IV paracetamol etc)
In your assignment, the following info should be included (if applicable):
the elimination half-life of each drug
• peak concentration of each drug
volume of distribution of each drug
the plasma protein binding profile of each drug
bioavailability of each drug
How are drugs X and Y metabolized?
How are drugs X and Y excreted?
Total systemic clearance of each drug
The steady-state concentration of each drug
Do drugs X and Y undergo first-pass effect?
•
the daily dose of each drug for a 70kg male patient (assume that the patient does not have
co-morbidities)
•
If drug X is given as IV infusion, what should the maintenance dose be?
If drug Y is given as IV infusion, what should the maintenance dose be?
•
If drug X is given as IV infusion, what should the rate of infusion be? Fast, slow? Explain
the reason.
•
If drug Y is given as IV infusion, what should the rate of infusion be? Fast, slow? Explain
the reason.
•
Is there any condition or disease state in which dose adjustment of each drug is required?
(such as renal disease or liver disease)
This activity is intended to build your experience with accessing the primary pharmacokinetics
data and identifying relevant reports of altered drug ADME processes. Page limit will be a
maximum of 2 pages with Times New Roman 12. There will be one space between the lines.
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