B. To anesthetize a patient, there is a 10 ml bottle of Ketamine at a 10% concentration. If the dose of Ketamine in cats is 15 mg/Kg and the cat weighs 4 pounds. Calculate a) Weight of the cat in kg. b) mg of Ketamine needed to anesthetize the cat. c) Volume in ml of Ketamine. Answer: a) 1.82kg b) 27.3mg c) 0.27ml C. A 15-lb patient presents acute post-surgical pain. To treat the pain, there are ampoules of fentanyl at a concentration of 1mg/2ml. If the dose of fentanyl is 5µg/Kg, calculate a) the dose in mg of fentanyl needed for the patient and b) the volume in ml to be injected into the patient. Answer: = a) 0.034mg b) 0.06ml
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- SOLVE THE FOLLOWING PROBLEMS OF DOSE CALCULATION, SHOW THE CALCULATIONS FOR EACH OF THEY: 10. To anesthetize a patient, a 10 ml bottle of Ketamine is available at a concentration at 10% If the Ketamine dose in patients is 15 mg/Kg and the patient weighs 4 lbs. Calculate: a) Weight of the patient in Kg. b) mg of Ketamine needed to anesthetize the patient. c) Volume in ml of Ketamine.18. Esmolol 1.2 g in 500 mL D5W has been ordered at a rate of 100 mcg/kg/min for a client weighting 103.2 kg. Determine the following: a) dosage in mcg/min: b) rate in mL/hr c) Is the dosage administered to the client safe?After oral administration of single 250 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 50 mg.hr/L. After intravenous bolus administration of 100 mg, the AUC was 100 hr/L. explain the way plz What is the the absolute bioavailability of the drug from the tablet applied orally? (10. SLAYT) A) 60 % B) 20 % C) 50 % D) 75 % E) 40 %
- 1. Demonstrate the procedure for arriving at the answer. A. To anesthetize a patient, there is a 10 ml bottle of Ketamine at a 10% concentration. If the dose of Ketamine in cats is 15 mg/Kg and the cat weighs 4 pounds. Calculate a) Weight of the cat in kg. b) mg of Ketamine needed to anesthetize the cat. c) Volume in ml of Ketamine. Answer: a) 1.82kg b) 27.3mg c) 0.27ml B. A 15-lb patient presents acute post-surgical pain. To treat the pain, there are ampoules of fentanyl at a concentration of 1mg/2ml. If the dose of fentanyl is 5ug/Kg, calculate a) the dose in mg of fentanyl needed for the patient and b) the volume in ml to be injected into the patient. Answer: = a) 0.034mg b) 0.06mlAs a prescriber, you need to write a prescription for codeine syrup (25 mg/5 mL) for a patient with swallowing difficulties. You want to prescribe a sufficient amount to give a dose of 30 mg four times a day for 2 weeks. i) How much is required for the required dose? ii) How much is required for a two-week supply?After oral administration of single 100 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 20 mg.hr/L. After intravenous bolus administration of 20 mg, the AUC was 10 mg.hr/L. Calculate the absolute bioavailability of the drug from the tablet applied orally. (10. SLAYT) A) 60% B) 20% C) 40% D) 50% E) 75% What sould be the minimum solubility of an active substance (its molecular weight:500) in the dissolution media to be chosen in order to ensure the sink condition in the paddle method by using a 1 liter volume of beaker of a tablet (its dose strength is 100 mg and tablet weight is 200 mg? (4. SLAYT) 1 mg/ml 200 mg/ml 20 mg/ml 5 mg/ ml 10 mg/ ml
- Concentration (mg/L) Time (hours) Sustained-Release Tablet Oral Solution 0.5 2.26 19.80 1 4.57 18.31 1.5 5.27 15.49 2 6.73 12.37 7.36 9.62 4 7.40 6.85 5 7.50 5.52 6.24 3.10 8. 4.70 1.79 12 2.76 1.587) Elroscin 75 meq is ordered. This medicatiun is quailable in 0.025 025mg tablefs . How many tablets doyou give :A drug has been developed for oral administration as a rapidly dissolving capsule. This drug is also available as an intravenous formulation. Pharmacokinetic studies with both formulations in a relevant patient population provided the following values for absorption rate constant, clearance, volume of distribution and bioavailability: ka = 1.0 h-1; Cl = 9 L/h; V = 90 L; and F = 0.8. Calculate the drug concentration (in the blood) 8 h after a 1000 mg dose is administered orally.
- mL b) Order of Ex.12: Calculate the following injectable dosages. a) Order of dosage: Lasix 40 mg intramuscularly. Supply: Lasix 10 mg/mL Give: dosage: Atropine 0.4 mg intramuscularly one hour pre-operatively. Supply: Atropine 1/150 grain/mL (or 0.0067 grain/mL) Give: dosage: Valium 7.5 mg intramuscularly stat. Supply: Valium 10. mg/mL Give: _mL Ex.13: Use the given table to determine the following. 23.2 g ice mL c) Order of cm3 = g table salt 25.0 cm3 mL 102.2 g gold = g/mL mg/L Ex.14: A cube of metal has a mass of 14.6 g and its sides 3 = m3 density of ethanol = are 12.3 mm. What is the identity of this metal? cmAnswer the following step by step A) If Dalmane is available as 15 mg capsules, what dosage is given with 2 capsules? B) Using 0.5 mg/kg of body weight for atropine by aerosol, what dose is needed for a 75-kg man? C) If Tempra is available as 120 mg/ 5 ml, how much dose is there in one-half teaspoon?How many ml is needed to fill this prescription Gabapentin liquid 300mg/5ml 300 mg po TID x 30 days A) 90ml B) 450ml C) 300ml D) 150ml