Assume a fragment of two-stranded antiparallel β-structure is 3.3 nm long. What is the approximate number of amino acids in this fragment?

Q: Outline the principle of how you would synthesise a library of approximately 1000 10-residue…

A: INTRODUCTION Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of…

Q: 1.) What do the first four letters represent in the polypeptide sequence of SARS-CoV-2 surface…

A: Since you have posted multiple questions, we will answer the first one for you. If you want a…

Q: Alanine has a strong tendency to form α-helix. A biochemist synthesized a polypeptide consisting of…

A:

Q: Calculate the fraction of Arginine that has its side chain deprotonated at pH 7.5.

A: Arginine is an amino acid that has a basic nature of side chain. Its pKa (negative log of…

Q: A different Fab fragment binds to lysozyme with a dissociation constant of Kd=10-6 M. A 1 nM (10-9…

A: Consider the following reaction: where P is the protein, L is the ligand and k1 and k2 are rate…

Q: SYNZIPS are a-helices that can be used in synthetic biology to create coiled-coil interactions…

A: Secondary structure of protein describes the special arrangement of its main chain atoms, without…

Q: 5′ - A U G C A A U A C A A U C C G G A A U G A - 3′ Give the primary structure of the protein that…

A: The translation is the process of synthesis of amino acids from the mRNA. During the translation…

Q: In BLOSUM62 matrix, a conserved Tryptophan position has score S(W,W) = 11, but a conserved Leucine…

A: BLOSUM is a block substitution matrix that is used to analyze and identify the best possible…

Q: Bacteriorhodospin (Mw = 26 kDa) is a protein with purple colour. The protein acts as a…

A: The bacteria archaea use the protein Bacteriorhodopsin. It works as a proton pump. It is found in…

Q: A protein contains three 60-kD polypeptides and six 20-kD polypeptides. Each 60-kD chain is…

A: Electrophoresis means migration of charged particles under the influence of an electric…

Q: Give two reasons to explain why a proline residue in the middle of an a helix is predicted to be…

A: Proline either breaks or kinks a helix.

Q: Purification of a protein of unknown structure has been achieved. The natural protein has a…

A: Proteins are polymers of amino acids and form primary structure. It can form secondary, tertiary and…

Q: This problem concerns a "typical" tyrosine residue found on the surface of a globular protein. a) If…

A: Tyrosine (Tyr or Y) is an aromatic amino acid that can be naturally produced by the body using…

Q: Bovine ribonuclease folds with ΔH° = -280 kJ mol-1 and ΔS° = -0.79 kJ mol-1 K -1. Assume ΔH° and ΔS°…

A: The basis for predicting spontaneity of a reaction is based on (ΔG), the change in G, at constant T…

Q: Some bacteria produce poly-γ-glutamic acid, a polymer in which the amino group of each glutamate…

A: Poly-γ-glutamic acid (γ-PGA) is a highly promising polymer that is non-toxic, non-immunogenic and…

Q: A synthetic polypeptid made up of L-glutamic acid residues is in a random coil configuration at pH…

A: Hydrophobic effect: non-polar side groups that do not ionize interact with other non-polar side…

Q: Draw the full structure of the one predominant form of val-asp-asp-arg fragment as it would exist at…

A: Amino acid is a molecule which group together to form proteins . Amino acid can be acidic , neutral…

Q: For the structure shown on the figure - qualitatively draw Ramachandran plot. Assume a mixture of…

A: Ramachandran plot is plot used to visualize energetically allowed regions for the peptide backbone…

Q: The following are sequences from three different alpha helices found in human proteins:…

A: The proteins are constituted of twenty naturally occurring amino acids connected via peptide…

Q: novel protein runs to give a single band on SDS PAGE (45kDa) and three bands on native PAGE.…

A: A novel protein runs to give a single band on SDS PAGE (45kDa) and three bands on native PAGE.…

Q: Trypsin cleaves polypeptide chains at the carboxyl side of a lysine or arginine residue.…

A: Trypsin is a serine protease found in the digestive system of many vertebrates. It helps in breaks…

Q: Jacqueline isolated an interesting new protein from the broth of a yeast culture. After purification…

A: The minimum molecular weight of the isolated protein was calculated as                Residue% =…

Q: This problem concerns a "typical" tyrosine residue found on the surface of a globular protein. a)…

A: The side chain of tyrosine is ionizable. It has a pKa of 10.1. An ionizable group exists…

Q: Fluorescent proteins like the green fluorescent protein (GFP) found in jellyfish are a class of…

A: Amino acids can be broadly divided into hydrophilic (water loving) and hydrophobic (water hating)…

Q: A protein has been sequenced after cleavage of disulfide bonds. The protein is known to contain 3…

A: Proteins are macromolecules formed by amino acids. A total of 20 different amino acids exist in…

Q: Using the letter “R" to indicate amino acid side chain, draw the following: A. The backbone atoms…

A: Beta-sheets come in the category of secondary structure of proteins. In parallel beta-sheets, two…

Q: A heptapeptide was found to have an amino acid composition of Asp, Leu, Lys, 2 Met, Phe and Tyr. (a)…

A: Proteins are important biomolecules in that it plays an important role in many biological functions.…

Q: You are working on a protein with the following sequence in an area of interest.…

A: Proteins are made up of different amino acids. Some amino acids have ionizable side chains. All…

Q: Assume that the translational error frequency, δ, is 1 x 10–4.(a) Calculate the probability of…

A: mRNAs are used to form protein by translation. The translation is performed using ribosomes, t-RNA…

Q: The ribosome can transfer any peptidyl group from the P-site tRNA to any aminoacyl group on the…

A: Proteins or polypeptides are sequence of amino acids which are linked by peptide bond or amide bond.…

Q: You have discovered a novel protein that has a pl = 5.5. To study the functional properties of this…

A: pI of protein is directly proportional to the pKa of amino acids.

Q: What is a helix-turn-helix motif?   secondary structure in which an α helix is separated from a β…

A: Introduction Motifs are the super secondary structure formed by the combinations of secondary…

Q: PfCRT is found to have 10 peaks on a hydropathy plot given its primary sequence. Researchers also…

A: Proteins are linear polymers of amino acids attached to peptide bonds. Now the primary structure…

Q: What would the order of migration be (bottom to top in the gel) in a SDS-PAGE for the following…

A: Introduction: Sodium dodecyl sulfate-polyacrylamide electrophoresis (SDS-PAGE) is an analytical…

Q: Assume that the translational error frequency, 8, is 1 × 10-4. (a) Calculate the probability of…

A: The translation is the process of making a polypeptide chain from mRNA. The translation is catalyzed…

Q: In a 0.1 M lysine solution, what are the individual concentrations of the protonated C-terminus…

A: In a 0.1 M solution of lysine, the protonated form of the amino acid has a concentration equal to…

Q: Approximate molecular weight for an unknown protein from gel-filtration experiment is 130 kDa.…

A: Given Values: Molecular weight obtained from gel-filtration experiment = 130 kDa Weight of the…