Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Concept explainers

Question
Based on the NCBI blast below Are there any pathogenic missense mutations in the human gene FGFR3? Also do they have any identical amino acids to prove a mouse is the best model to test the fgfr3 gene?
fibroblast growth factor receptor 3 isoform 3 precursor [Homo sapiens]
Sequence ID: NP_001156685.1 Length: 808 Number of Matches: 1
Range 1: 1 to 808
Score
Expect Method
Gaps
1478 bits(3827) 0.00) Compositional matrix adjust. 745/808(92%) 765/808(94%) 6/808 (0%)
58
Query 1 MVVPACVLVFCVAV--VAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELS
CVAV VAGA+SE G EQRVV RAAEVPGPEP QQEQ+ FGSGD VELS
Sbjct 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGOQEQLVFGSGDAVELS
60
Query 59
Sbjct 61
Query 119
CHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDAGVYSCQHRL TRRVLCH 118
C PPGG P GPTVW KDGTGLV S R+LVGPQRLQVLNASHED+G YSC+ RLT+RVLCH
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPORLOVLNASHEDSGAYSCRQRL TQRVLCH
120
M PAC L
Identities
Positives
FSVRVTDAPSSGDDEDGEDVAE ----DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 174
FSVRVTDAPSSGDDEDGED AE DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
180
Sbjct 121
Query 175
Sbjct 181
234
240
Query
294
235 YTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
YTLDVLERSPHRPILQAGLPANQTA+LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Query 295
300
DGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQA
354
Sbjct 301
DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA
360
Query 355 AEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRLRSPPKKGLGSPTVHKVSRFP 414
AEEEL+E DEAGSVYAG+LSYGV FFLFILVVAAV LCRLRSPPKKGLGSPTVHK+SRFP
Sbjct 361 AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP 420
474
480
LKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPL
Query 415
Sbjct 421
LKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPL
Query 475
Sbjct 481
GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 534
GEGCFGQVVMAEAIGIDKDR AKPVTVAVKMLKDDATDKDLSDLVS EMEMMKMIGKHKNI
GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 540
INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRL PEEQLTCKDLVSCA 594
INLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPG+DYSFD C+ PEEQLT KDLVSCA
INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600
Query 535
Sbjct 541
Query 595
YQVARGMEYLASQKCIHRDLAARNVLV ONVMKIADFGLARDVHNLDYYKKTTNGRLPV 654
Sbjct 601
YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV
YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660
Query 655 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAS 714
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA+
Sbjct 661 KWMAPEALFDRVYTHOSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN
720
Query 715 CTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTP 774
CTHDLYMIMRECWHA PSQRPTFKQLVEDLDR+LTVTSTDEYLDLS PFEQYSPGGQDTP
Sbjct 721
CTHDLYMIMRECWHAAPSORPTFKOLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 780
Query 775
Sbjct 781
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
NPTPSISWLKNG+EFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
DGTPYVTVLKSWISE+VEAD RLRLANVSERDGGEYLCRATNFIGVAEKAFWL VHGP+A
LKROVSLESN+SM+SNTPLVRIARLSSGEGP LANVSELELPADPKWELSR RLTLGKPL
SSSSSGDDSVF THDL LPPGPPSNGGPRT 802
SSSSSGDDSVF HDLLPP PPS+GG RT
SSSSSGDDSVFAHDL LPPAPPSSGGSRT
808
Frame
expand button
Transcribed Image Text:fibroblast growth factor receptor 3 isoform 3 precursor [Homo sapiens] Sequence ID: NP_001156685.1 Length: 808 Number of Matches: 1 Range 1: 1 to 808 Score Expect Method Gaps 1478 bits(3827) 0.00) Compositional matrix adjust. 745/808(92%) 765/808(94%) 6/808 (0%) 58 Query 1 MVVPACVLVFCVAV--VAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELS CVAV VAGA+SE G EQRVV RAAEVPGPEP QQEQ+ FGSGD VELS Sbjct 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGOQEQLVFGSGDAVELS 60 Query 59 Sbjct 61 Query 119 CHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDAGVYSCQHRL TRRVLCH 118 C PPGG P GPTVW KDGTGLV S R+LVGPQRLQVLNASHED+G YSC+ RLT+RVLCH CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPORLOVLNASHEDSGAYSCRQRL TQRVLCH 120 M PAC L Identities Positives FSVRVTDAPSSGDDEDGEDVAE ----DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 174 FSVRVTDAPSSGDDEDGED AE DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180 Sbjct 121 Query 175 Sbjct 181 234 240 Query 294 235 YTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP YTLDVLERSPHRPILQAGLPANQTA+LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP Sbjct 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP Query 295 300 DGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQA 354 Sbjct 301 DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA 360 Query 355 AEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRLRSPPKKGLGSPTVHKVSRFP 414 AEEEL+E DEAGSVYAG+LSYGV FFLFILVVAAV LCRLRSPPKKGLGSPTVHK+SRFP Sbjct 361 AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP 420 474 480 LKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPL Query 415 Sbjct 421 LKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPL Query 475 Sbjct 481 GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 534 GEGCFGQVVMAEAIGIDKDR AKPVTVAVKMLKDDATDKDLSDLVS EMEMMKMIGKHKNI GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 540 INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRL PEEQLTCKDLVSCA 594 INLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPG+DYSFD C+ PEEQLT KDLVSCA INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600 Query 535 Sbjct 541 Query 595 YQVARGMEYLASQKCIHRDLAARNVLV ONVMKIADFGLARDVHNLDYYKKTTNGRLPV 654 Sbjct 601 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660 Query 655 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAS 714 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA+ Sbjct 661 KWMAPEALFDRVYTHOSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN 720 Query 715 CTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTP 774 CTHDLYMIMRECWHA PSQRPTFKQLVEDLDR+LTVTSTDEYLDLS PFEQYSPGGQDTP Sbjct 721 CTHDLYMIMRECWHAAPSORPTFKOLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 780 Query 775 Sbjct 781 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG NPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT NPTPSISWLKNG+EFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT DGTPYVTVLKSWISE+VEAD RLRLANVSERDGGEYLCRATNFIGVAEKAFWL VHGP+A LKROVSLESN+SM+SNTPLVRIARLSSGEGP LANVSELELPADPKWELSR RLTLGKPL SSSSSGDDSVF THDL LPPGPPSNGGPRT 802 SSSSSGDDSVF HDLLPP PPS+GG RT SSSSSGDDSVFAHDL LPPAPPSSGGSRT 808 Frame
Score
Expect Method
Positives
Gaps Frame
1506 bits(3898) 0.0() Compositional matrix adjust. 736/796(92%) 755/796(94%) 6/796(0%)
Query 1
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
PAC L CVAV VAGA+SE G EQRVV RAAEVPGPEP QQEQ+ FGSGD VELS
MVVPACVLVFCVAV--VAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELS 58
Sbjct 1
Query 61
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTORVLCH 120
Sbjct 59 CHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLOVLNASHEDAGVYSCQHRLTRRVLCH 118
Query 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
174
Sbjct 119
FSVRVTDAPSSGDDEDGEDVAEDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAG
Query 181
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWS LVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNG+EFRGEHRIGGIKLRHOQWS LVMESVVPSDRGNYTCVVENKFGSIROT
Sbjct 175 NPTPSISWLKNGKEFRGEHRIGGIKLRHOOWS LVMESVVPSDRGNYTCVVENKFGSIROT 234
M
C PPGG P GPTVW KDGTGLV S R+LVGPQRLQVLNASHED+G YSC+ RLT+RVLCH
FSVRVTDAPSSGDDEDGED AEDTG
Identities
APYWTRPERMDKKLLAVPAANTVRFRCPAAG
Query 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTA+LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct 235 YTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 294
Query 301 DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA
360
DGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQA
354
Sbjct 295
Query 361
AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP 420
AEEEL+E DEAGSVYAG+LSYGV FFLFILVVAAV LCRLRSPPKKGLGSPTVHK+SRFP
Sbjct 355 AEEELMETDEAGSVYAGVLSYGVVFFLFILWVAAVILCRLRSPPKKGLGSPTVHKVSRFP 414
Query 421 LKROVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPL
480
474
Sbjct 415
Query 481 GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML KDDATDKDLSDLVSEMEMMKMIGKHKNI 540
Sbjct 475 GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKML KDDATDKDLSDLVSEMEMMKMIGKHKNI 534
Query 541 INLLGACTQGGPLYVLVEYAAKGNL REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600
INLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPG+DYSFD C+ PEEQLT KDLVSCA
INLLGACTOGGPLYVLVEYAAKGNL REFLRARRPPGMDYSFDACRL PEEQLTCKDLVSCA 594
Sbjct 535
Query 601 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660
YOVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV
Sbjct 595 YOVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV
654
Query 661
KWMAPEAL FDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN 720
Sbjct 655
714
Query 721
CTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 780
CTHDLYMIMRECWHA PSQRPTFKQLVEDLDR+LTVTSTDEYLDLS PFEQYSPGGQDTP
CTHDLYMIMRECWHAVPSORPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTP 774
Sbjct 715
Query 781
Sbjct 775
DGTPYVTVLKSWISE+VEAD RLRLANVSERDGGEYLCRATNFIGVAEKAFWL VHGP+A
LKROVSLESN+SM+SNTPLVRIARLSSGEGP LANVSELELPADPKWELSR RLTLGKPL
LKROVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPL
GEGCFGQVVMAEAIGIDKDR AKPVTVAVKML KDDATDKDLSDLVS EMEMMKMIGKHKNI
SSSSSGDDSVFAHDLL 796
SSSSSGDDSVF HDLL
SSSSSGDDSVF THDLL 790
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA+
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAS
expand button
Transcribed Image Text:Score Expect Method Positives Gaps Frame 1506 bits(3898) 0.0() Compositional matrix adjust. 736/796(92%) 755/796(94%) 6/796(0%) Query 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60 PAC L CVAV VAGA+SE G EQRVV RAAEVPGPEP QQEQ+ FGSGD VELS MVVPACVLVFCVAV--VAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELS 58 Sbjct 1 Query 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTORVLCH 120 Sbjct 59 CHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLOVLNASHEDAGVYSCQHRLTRRVLCH 118 Query 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180 174 Sbjct 119 FSVRVTDAPSSGDDEDGEDVAEDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAG Query 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWS LVMESVVPSDRGNYTCVVENKFGSIRQT 240 NPTPSISWLKNG+EFRGEHRIGGIKLRHOQWS LVMESVVPSDRGNYTCVVENKFGSIROT Sbjct 175 NPTPSISWLKNGKEFRGEHRIGGIKLRHOOWS LVMESVVPSDRGNYTCVVENKFGSIROT 234 M C PPGG P GPTVW KDGTGLV S R+LVGPQRLQVLNASHED+G YSC+ RLT+RVLCH FSVRVTDAPSSGDDEDGED AEDTG Identities APYWTRPERMDKKLLAVPAANTVRFRCPAAG Query 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300 YTLDVLERSPHRPILQAGLPANQTA+LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP Sbjct 235 YTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 294 Query 301 DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA 360 DGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQA 354 Sbjct 295 Query 361 AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP 420 AEEEL+E DEAGSVYAG+LSYGV FFLFILVVAAV LCRLRSPPKKGLGSPTVHK+SRFP Sbjct 355 AEEELMETDEAGSVYAGVLSYGVVFFLFILWVAAVILCRLRSPPKKGLGSPTVHKVSRFP 414 Query 421 LKROVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPL 480 474 Sbjct 415 Query 481 GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML KDDATDKDLSDLVSEMEMMKMIGKHKNI 540 Sbjct 475 GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKML KDDATDKDLSDLVSEMEMMKMIGKHKNI 534 Query 541 INLLGACTQGGPLYVLVEYAAKGNL REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600 INLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPG+DYSFD C+ PEEQLT KDLVSCA INLLGACTOGGPLYVLVEYAAKGNL REFLRARRPPGMDYSFDACRL PEEQLTCKDLVSCA 594 Sbjct 535 Query 601 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660 YOVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV Sbjct 595 YOVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 654 Query 661 KWMAPEAL FDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN 720 Sbjct 655 714 Query 721 CTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 780 CTHDLYMIMRECWHA PSQRPTFKQLVEDLDR+LTVTSTDEYLDLS PFEQYSPGGQDTP CTHDLYMIMRECWHAVPSORPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTP 774 Sbjct 715 Query 781 Sbjct 775 DGTPYVTVLKSWISE+VEAD RLRLANVSERDGGEYLCRATNFIGVAEKAFWL VHGP+A LKROVSLESN+SM+SNTPLVRIARLSSGEGP LANVSELELPADPKWELSR RLTLGKPL LKROVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPL GEGCFGQVVMAEAIGIDKDR AKPVTVAVKML KDDATDKDLSDLVS EMEMMKMIGKHKNI SSSSSGDDSVFAHDLL 796 SSSSSGDDSVF HDLL SSSSSGDDSVF THDLL 790 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA+ KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAS
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