How may genes play a role in the susceptibility of inheriting cancers? The reproductive system discusses reproductive disorders like breast and prostate cancer. So, if an individual has a mutated gene such as the BRCA gene do you think the environment could play a role in gene expression?
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How may genes play a role in the susceptibility of inheriting cancers? The reproductive system discusses reproductive disorders like breast and prostate cancer. So, if an individual has a mutated gene such as the BRCA gene do you think the environment could play a role in gene expression?
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- What are predisposition genes? why are the responsible for cause of cancer ?Mutations in the BRCA genes have been shown to be related to a higher incidence of breast cancer in humans, and genetic tests are available that enable women to discover whether they carry versions of the gene associated with high risk. However, even early detection of breast cancer does not guarantee a cure. What considerations can you think of for and against advising women to take the tests? ·How do changes in gene expression relate to cell differentiation and specialization? Does every human cell have the same DNA, RNA or proteins?
- You examine a maternal effect protein that regulates cell division. Will a mutation in this gene display a defect in the mother with the mutation, or in her offspring who have not inherited the mutation?Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?Genetic mutations can provide insights into the mechanisms of complex cellular or developmental processes. How might your analysis of a genetic mutation be different depending on whether a particular mutation is recessive or dominant?
- examine the process of gene expression. Include the following: Explain the regulation of gene expression in eukaryotic cells. Discuss mechanisms by which gene expression may be altered. How do these alterations induce cancer-causing mutations in cell DNA? Explain how cancer is formed. Describe genetic changes found in cancer cells and how these changes lead to alterations in cell behavior. Determine whether proteome data can be utilized in genetic disorder diagnosis. Relate the Human Genome Project data to the analysis of cancer genes. Relates the Human Genome Project's utility in pharmacogenomics and personalized medicine to diagnose and treat cancerBRCA1 is a gene that codes for a tumor suppressor protein. If a person inherits a mutation in BRCA1, it greatly increases his or her risk of developing breast cancer. Are the cancer-causing mutations in the BRCA1 gene more likely to: A) not affect expression of the gene B) increase expression of the gene C) decrease expression of the geneCarefully distinguish between the terms differentiation and determination. Which phenomenon occurs initially during development?
- In 2010, the U.S. Department of Health and Human Services added alcoholic beverages to its list of known human carcinogens. Explain what types of cancer alcohol is related to; what steps should be taken to reduce the risk of developing alcohol-induced cancer; and what other factors, when combined with alcohol, increase the risk of developing cancer.Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to behave as a recessive gene?What significance do BRCA1 and BRCA2 have in regard to developing cancer, and what types of cancer are associated with these genes?
