Among the first antipsychotic drugs for the treatment of schizophrenia was haloperidol (Haldol), a competitive inhibitor of dopamine receptor sites in the central nervous system. но Haloperidol Br. (A) 1-Bromo-4-chlorobenzene COOCH3 COOCH, COOCH (В) (C) COOCH, + NH2 Methyl acrylate THN Fluoro- Succinic (F) benzene anhydride (E)
Among the first antipsychotic drugs for the treatment of schizophrenia was haloperidol (Haldol), a competitive inhibitor of dopamine receptor sites in the central nervous system. но Haloperidol Br. (A) 1-Bromo-4-chlorobenzene COOCH3 COOCH, COOCH (В) (C) COOCH, + NH2 Methyl acrylate THN Fluoro- Succinic (F) benzene anhydride (E)
Chapter16: Chemistry Of Benzene: Electrophilic Aromatic Substitution
Section16.4: Substituent Effects In Electrophilic Substitutions
Problem 11P
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Given this retrosynthetic analysis, propose a synthesis for haloperidol.
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