Although both hexokinase and phosphofructokinase catalyze irreversible steps in glycolysis and the hexokinase-catalyzed step isfirst, phosphofructokinase is nonetheless the pacemaker of glycolysis.What does this information tell you about the fate of the glucose 6-phosphate formed by hexokinase?Glucose 6-phosphate must be unstable and release its phosphoryl group over time.Glucose 6-phosphate must be utilized by other metabolic pathways.Glucose 6-phosphate must allosterically inhibit phosphofructokinase, but not hexokinase.Glucose 6-phosphate must be wasted when it is produced in excess.

The metabolic process known as glycolysis, which takes place in the cytosol, the liquid portion of…

Answered: Although both hexokinase and…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Why is there such a large range of ∆G for the second step of glycolysis?
The intracellular use of glucose and glycogen is tightly regulated at four points. To compare the regulation of glycolysis when oxygen is plentiful and when it is depleted, consider the utilization of glucose and glycogen by rabbit leg muscle in two physiological settings: a resting rabbit and a rabbit that saw its mortal enemy, the coyote, and is dashing to its burrow. For each setting determine the relative levels of the following metabolites: Metabolite Resting.rabbit Dashing rabbit AMP ( Select) [ Select ) ATP ( Select) ( Select ) Citrate [ Select) ( Select ) Acetyl-CoA [ Select } ( Select ) >
In the Cori cycle, the lactate product of glycolysis in muscle is transformedback into glucose by the liver. (a) List the enzymes involved in the lactate → glucose pathway. (b) What is the net gain/loss of ATP for one round of the Cori cycle (glucose → lactate → glucose)?
Two reactions are shown below. These reactions are directly coupled in cells by an enzyme called hexokinase, which is a key enzyme in glycolysis. It is generally the case that reactions that are directly coupled by enzymes share some common reactants. What is the net reaction when these two reactions are combined? Glucose + Inorganic Phosphate + ATP + Water → Glucose 6-phosphate + ADP Glucose + ATP + Water → Glucose 6-phosphate + ADP + Inorganic Phosphate Glucose + ATP → Glucose 6-phosphate + Inorganic Phosphate Glucose + ATP → Glucose 6-phosphate + ADP
How do the ligand (substrate) and the protein/enzyme predominantly interact? sigma bonds O Metallic bonds O Pi bonds O lonic bonds O Weak non-covalent bonds
The last step of glycolysis converts phosphoenolpyruvate to pyruvate. Several intermediates involved in the steps for the conversion of pyruvate to phosphoenolpyruvate via gluconeogenesis are given. Choose and place the right intermediates produced from these steps in the correct order. (Select from: Oxaloacetate, Ethanol, Pyruvate, Ketoglutarate, Phosphoenolpyruvate, Malate, Fumarate) _________ → _________ → _________ → __________ → Phosphoenolpyruvate
How many total moles of ATP are created in a cell with an ATP synthase with 8 c subunits for every 28 moles of glucose that is completely oxidized in glycolysis and the Krebs cycle? Assume that NADH is transported by the malate aspartate shuttle.
An investigator briefly incubates an actively respiring bacterial culture with [1-14 C]glucose and isolates the glycolytic and citric acid cycle intermediates. Where is 14 C located in each of the intermediates listed? Consider only the initial incorporation of 14C in the first pass of labeled glucose through the pathways. fructose 1,6-bisphosphate glyceraldehyde 3-phosphate phosphoenolpyruvate acetyl-CoA citrate ☐ ☐ ☐ ☐ ☐ ☐ ☐ a-ketoglutarate oxaloacetate Answer Bank C-4 C-1 C-3 C-2
Pyruvate, labeled with 14C at C-1, is incubated with 13C labeled bicarbonate and added to intact yeast cells (yeast can perform gluconeogenesis). What and where will these labels appear on the resulting glucose produced through gluconeogenesis? What and where will these labels appear on ethanol produced through fermentation?
Step 4 of the pentose phosphate pathway converts ribulose-5-phosphate to ribose-5-phosphate. Which glycolytic reaction does this reaction resemble and what type of enzyme catalyzes it?
When the cells of our body are in dire need to synthesize Ribose 5 phosphate and it has already enough supply of NADPH, reverse non oxidative pathway of the HMP shunt pathway takes place. If the cell has 10 glucose 6 phosphate molecules, how many of these would be converted to Fructose 6 phosphate and how many to form glyceraldehyde 3 phosphate respectively to synthesize maximum number of Ribose 5 phosphate? 8:2 2:8 4:6 6:4
Pyridoxal phosphate is an important coenzyme in transamination reactions. We have seen this coenzyme before, in glycogen metabolism. Which enzyme in glycogen metabolism requires pyridoxal phosphate and what role does the coenzyme play in this enzyme?

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