Alterations in which of the following microbial cell binding sites is the most likely cause of this resistance? (A) Lanosterol demethylase (B) Peptidyl transferase (C) Thymidine kinase (D) Topoisomerase IV (E) uridine kinase
(59) A 60-year old woman with type-2 diabetes mellitus comes to the physician because of a 6-week history of a progressive rash under both breasts. She says that the rash irritability responded to use of an over-the-counter topical preparation containing clotrimazole, but the treatment has recently has become ineffective in relieving her symptoms. Physical examination shows a 10-cm of erythema with a mucous discharge under each breast. Her finger stick blood glucose concentration is 115 mg/dL. Microscopic examination of the discharge shows branching hyphae. The physician suspects that the causal organism in this patient is resistant to clotrimazole. Alterations in which of the following microbial cell binding sites is the most likely cause of this resistance?
(A) Lanosterol demethylase
(B) Peptidyl transferase
(C) Thymidine kinase
(D) Topoisomerase IV
(E) uridine kinase
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