Addition of 2° amine Can you please help me solve this? If possible, can you please draw the mechanism on paper and pencil? Addition of 2° amine H H R11 N R3 R4 C=O pH = 5 (R2) H
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- NOC XT Ph CH₂ Both primary and secondary amines add to a ß-unsaturated aldehydes and ketones to yield ß-amino aldehydes and ketones rather than the alternative imines. Under typical reaction conditions, both direct and conjugate modes of addition occur rapidly. But because the reactions are reversible, they generally proceed with thermodynamic control rather than kinetic control so the more stable conjugate addition product is often obtained to the complete exclusion of the less stable direct addition product. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions H H CH3NH₂ CH3 H-A :A Ph NHCH3 вон CH3 :A H-A 8bDraw the structure of a molecule that could be converted to cocaine via reductive amination. H+ NaBH3CN cocaine IMG_20220605_044753.jpg You 3 seconds ago Please explain the mechanism with steps(a) (b) (c) (d) (e) + Lysine H₂O + Hopi HO3P- HO OH i O: N OH A + HSCH 3 OH acetal formation imine formation enamine hydrolysis acyl substitution 1,4 addition
- The following three derivatives of succinimide are anticonvulsants and have found use in the treatment of epilepsy, particularly petit mal seizures. Ph Ph `N' `N' ČH3 ČH3 Methsuximide Ethosuximide Phensuximide Following is a synthesis of phensuximide. CN Ph CN Ph CN 1. NaOH, H2O 2. HC, Н20 NaOEt KCN Ph-CHO cOOEt H cOOEt NC COOEt 3. Нeat Ethyl cyanoacetate (A) (B) Benzaldehyde Ph Ph Ph CH;NH2 НООС СООН Et0oC COOEt `N' (C) (D) ČH3 Phensuximide Methsuximide is formed by a similar pathway to that shown for phensuximide. Draw the structure of the compound that reacts with ethyl cyanoacetate in the synthesis of methsuximide.a. What is the amine and coupling components of this azodye? H;CO- -N=N-Which C-O containing compound cannot make an enamine with the amine shown below? H. NH B OD O E OB Oc 3C O A E.
- X Answered - Incorrect • 1 attempt left Each of the three reactions below shows a Grignard reagent reacting with an unknown electrophile (1, 2 and 3) in the solvent diethyl ether to produce a product. All products are neutralized with HCl at the end of the reaction. Select the electrophiles from the list below that correspond to the reactions shown below: O Drag and drop options on the right- hand side to reorder and match with items on the left. Reordering may cause items on the right-hand side to swap positions. (1) i (2) vi (3) iv vii V ii II IIe) In the acetylation of alcohol with acetyl chloride, the overall yield of ester is improved by tl addition of tri-ethylamine. Explain. Triethylamine RO CH;COCI ROH CH3 Why is a product between acetyl chloride and tri-ethylamine (CH3CH2)3N not observed?Q10 4-ethyl-2-methylthiolane 3-ethyl-5-methylthiolane 5-methyl-3-ethylthiolene imidazo[2,1,b]oxazole O imidazo[1,2,b]oxazole oxazolo[2,1,b]imidazole Q12 * HN imidazolo [4,5,d]pyrimidine imidazolo [5,4,b]pyimidine imidazolo [4,5,b]pyrimidine Q11* HN. Ο Ο
- H₂C CH-COOH +CH,CH(CH,)NH, heat ال ال ال سي او Reaction C Incorrect heat H₂C=CC=C H₂ Reaction D H H CIN H py H₂ CH₂ CH₂ H₂C H I C "COOH +CH,CH(CH,NH, H CH₂ Incorrect Draw the amide formed when isopropylamine (CH₂CH(CH³)NH₂) (CH3CH(CH3)NH₂) is heated with each carboxylic acid. Include all hydrogen atoms. What did I do wrong? H V H-C H I H H H C-C H H 0 "1 H H с Hb с NH2 O N-methylhexanamide O 2-amino-N,N-diethylbenzamide 2-amino-N-methylbenzamide O N-ethyl-2-hydroxybutanamide 4-aminobenzamide N-ethyl-2-methylbutanamide Submit cyclopentyl acetate ethyl 3-hydroxy-2-methylbutanoate ethyl 3-oxobutanoate cyclopent-3-enyl propanoate ethyl 3-hydroxybutanoate cyclopent-3-enyl acetatea OH CH2CNHCH3 T CH3 d OH CHCHNHCH3 CH3 Ephedrine can be synthesized via reductive amination plus other necessary reactions. Predict the necessary reactants and reagents that will give the intermediate and final products shown.